Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT
Journal Title: International Journal of Reproductive BioMedicine - Year 2016, Vol 14, Issue 5
Abstract
Background: Despite major advances in assisted reproductive techniques, the implantation rates remain relatively low. Some studies have demonstrated that intrauterine infusion of granulocyte colony stimulating factor (G-CSF) improves implantation in infertile women. Objective: To assess the G-CSF effects on IVF outcomes in women with normal endometrial thickness. Materials and methods: In this randomized controlled clinical trial, 100 infertile women with normal endometrial thickness who were candidate for IVF were evaluated in two groups. Exclusion criteria were positive history of repeated implantation failure (RIF), endocrine disorders, severe endometriosis, congenital or acquired uterine anomaly and contraindication for G-CSF (renal disease, sickle cell disease, or malignancy). In G-CSF group (n=50), 300 µg trans cervical intrauterine of G-CSF was administered at the oocyte retrieval day. Controls (n=50) were treated with standard protocol. Chemical, clinical and ongoing pregnancy rates, implantation rate, and miscarriage rate were compared between groups. Results: Number of total and mature oocytes (MII), two pronuclei (2PN), total embryos, transferred embryos, quality of transferred embryos, and fertilization rate did not differ significantly between two groups. So there were no significant differences between groups in chemical, clinical and ongoing pregnancy rate, implantation rate, and miscarriage rate Conclusion: our result showed in normal IVF patients with normal endometrial thickness, the intrauterine infusion of G-CSF did not improve pregnancy outcomes.
Authors and Affiliations
Maryam Eftekhar, Robabe Hosseinisadat, Ramesh Baradaran, Elham Naghshineh
Keywords
Related Articles
- EP ID EP185880
- DOI -
- Views 135
- Downloads 0
Health-related quality of life in polycystic ovary syndrome patients: A systematic review
Background: Increasing attention to the concept of polycystic ovary syndrome (PCOS) health-related quality of life has led to the development of tool that aims to measure this concept. Objective: The purpose of this stud...
Bibliometric mapping and clustering analysis of Iranian papers on reproductive medicine in Scopus database (2010-2014)
Background: To meet the future challenges in the field of reproductive medicine in Iran, better understanding of published studies is needed. Bibliometric methods and social network analysis have been used to measure the...
The effect of 24 hours delay in oocyte maturation triggering in IVF/ICSI cycles with antagonist protocol and not-elevated progesterone: A randomized control trial
Background: The best time of final oocyte maturation triggering in assisted reproduction technology protocols is unknown. This time always estimated by combined follicular size and blood progesterone level. Objective: Th...
First successful pregnancies following embryo selection using Time-lapse technology in Iran: Case report
Background: Embryo selection is a vital part of in vitro fertilization (IVF) programs, with morphology-based grading systems having been widely used for decades. Time-lapse imaging combined with embryo morph kinetics may...
Association between electromagnetic field exposure and abortion in pregnant women living in Tehran
With great interest, we have read the article by Abad et al. entitled “Association between electromagnetic field exposure and abortion in pregnant women living in Tehran” that is published in International Journal of Rep...