EFFECT OF GYMNEMA SYLVESTRE METHANOLIC EXTRACT ON PANCREATIC PUTRESCINE LEVELS AGAINST ALLOXAN-INDUCED DIABETIC RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 1
Abstract
Objective: Gymnema sylvestre, a rare herb with significant medicinal values widely used as a naturopathic treatment for diabetes. This study demonstrates the antidiabetic potential and changes in the levels of pancreatic putrescine in G. sylvestre treated experimental rat models.Methods: Phytochemical analysis was carried out for methanolic leaf extract of G. sylvestre (GSME). Further, antidiabetic property and putrescine levels in alloxan-induced diabetic Wister albino rats were analyzed by high-performance liquid chromatography method.Results: The GSME (500 mg/kg b/w) was administered daily up to 15 days in diabetic rats against standard drug metformin (500 mg/kg b/w). At the end of the experiments, the increased body weights were noted in the diabetic control groups, while there was reduction in blood glucose level, total protein, liver glycogen, glutathione, glutathione peroxidase, and blood catalase, respectively.Conclusion: GSME at the dose of (500 mg/kg b/w) brings about significant beneficial effects in various physiological parameters and level of putrescine altered during diabetic manifestations, and these effects are quite comparable with the standard drug, metformin.
Authors and Affiliations
Jothi Muniyandi M, Benno Susai Vijayakumar A
Keywords
Related Articles
- EP ID EP607140
- DOI 10.22159/ajpcr.2019.v12i1.28117
- Views 123
- Downloads 0
COMPARISON OF THE EFFECTS OF NIGELLA SATIVA OIL AND LASER ON TREATMENTS ON EXPERIMENTAL WOUND HEALING IN RATS
Objective:The study investigated the influences of treatment with Nigella sativa oil and laser therapy on wound healing in rats. The period of the inflammatory phase reduced through both laser and N. sativa oil actions;...
CHEMICAL COMPOSITION, ANTIMICROBIAL, AND ANTIOXIDANT ACTIVITIES OF TWO MOROCCAN THYMUS ESSENTIAL OILS
Objective: The aim of the present study is to investigate chemical constituents of Thymus riatarum and Thymus blecherianus essential oils (EOs) as well as to evaluate, for the first time, their antioxidant effect and ant...
EVALUATION OF THE PROPHYLACTIC ROLE OF INDIAN SHRIMP IN ALUMINUM CHLORIDE-INDUCED ALZHEIMER’S DISEASE ON EXPERIMENTAL RATS
Objective: This work was aimed to investigate the prophylactic and therapeutic role of Indian shrimp in aluminum chloride-induced Alzheimer’s disease (AD) in rats. Methods: The male Wistar rats were selected and divided...
EVALUATION OF PRICE DISPARITY AMONG GENERIC MEDICINES IN INDIA
Objective: Even though the generic medicines are considered to be a cheaper option compared to the branded medicines in India, there is a need to study the price disparity among the generic medicines. Hence, the present...
MORPHOMETRIC STUDY OF PROXIMAL FEMUR AND ITS CORRELATION WITH BONE MINERAL DENSITY. A CROSS-SECTIONAL STUDY
Objective: Proximal femoral morphometries such as hip axis length (HAL), femoral neck (FN) axis length (FNAL), and FN shaft angle (FNSA) are important parameters for prediction of fracture risk. These parameters are affe...