Effect of Haemodialysis on Oxidative Stress in Chronic Kidney Disease Patients
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 2
Abstract
ABSTRACT Introduction: The progressive damage to the kidney by oxidative stress and depletion of nitric oxide have been pointed out in recent years. Oxidative stress has been implicated to various mechanisms leading to accumulation of superoxide anions. Aim: We have estimated serum levels of Superoxide Dismutase (SOD), Ceruloplasmin, Total Antioxidant (TAO) and Malondialdehyde (MDA) to study the oxidative stress in chronic kidney disease as well as compare it with its post haemodialysis status. Materials and Methods: The study group consisted of 96 individuals with chronic kidney disease (cases) and 60 age/sex matched healthy individuals (control). Blood sample was collected from cases before and after haemodialysis as well as from the control group. Blood sample was processed and estimated for MDA, SOD, TAO and ceruloplasmin. Student’s t-test was used to find the significance and Pearson correlation was used to find the degree of relationship between the study parameters. Results: A statistically significant (p<0.001) increase in serum MDA was observed in cases compared to controls. Serum SOD, ceruloplasmin and TAO levels were decreased in cases in chronic kidney disease compared to control group. The decrease in serum ceruloplasmin and TAO activity was statistically significant (p<0.001). After haemodialysis, statistically significant increase in serum MDA level (p=0.004) as well as ceruloplasmin (p<0.001) level were observed. However, serum SOD and TAO activity were decreased significantly (p<0.001). Conclusion: In chronic kidney disease oxidative stress is higher, which is further increased after haemodialysis as indicated by increased MDA levels and decreased SOD and TAO activity.
Authors and Affiliations
Ashok Kumar Jeppu, Sushith . , Asha Augusty, Reshma Kiran Kumar, Prathima Mangalore Balakrishna, Prasanna Kumar Rao Jeppu, Kavitha Ashok Kumar
Keywords
Related Articles
- EP ID EP558572
- DOI 10.7860/JCDR/2019/38094.12579
- Views 89
- Downloads 0
Comparison of the Effect of Fluoride Varnish, Chlorhexidine Varnish and Casein Phosphopeptide- Amorphous Calcium Phosphate (CPP-ACP) Varnish on Salivary Streptococcus mutans Level: A Six Month Clinical Study
Introduction: Dental caries is the most widespread disease which has a multi factorial origin. Streptococcus mutans is considered to be the chief pathogen in its development. Different varnishes are available which can b...
Pneumatosis Cystoides Intestinalis
Images in Medicine
Impact of Occupational Lead Exposure on Liver and Kidney Function Tests on Silver Jewellery Workers
ABSTRACT Introduction: In unorganised silver jewellery industry, lead fumes and lead oxide dusts are generated while manufacturing the silver ring and the workers involved in this business are highly exposed to lead. Thi...
Ventilatory Defects in Toll Plaza Workers at Sriperumbudur Toll Plaza, Tamil Nadu, India
ABSTRACT Introduction: Highways are the arteries of the nation. As fast as they grow, many toll plazas are installed to collect the taxes, ignoring the health hazards of the toll collectors due to the air pollution cause...
Microtia in All the Siblings of a Family: A Rare Case
Images in Medicine