Abstract

Aim: The aim of present study is to evaluate the efficacy of Lornoxicam in attenuating haemodynamic response to laryngoscopy and intubation in a placebo controlled double blinded study. Materials and Methods: A clinical comparative study of attenuation of sympathetic response to laryngoscopy and intubation was done in 60 patients posted for elective surgery. 60 cases are divided in to two groups 30 in each group. Group-1 was control group. Group-2 was lornoxicam group. Results: In group-1, a maximum increase in heart rate of 32.5%, increase in systolic and diastolic blood pressure of 41% and 34.6% respectively, increase in mean arterial pressure of 38.5%, rate pressure product of 87% was observed after 1 min of laryngoscopy and intubation. In group-2, a maximum increase in heart rate of 9.3%, increase in systolic and diastolic blood pressure of 13.5% and 7.6% respectively, increase in mean arterial pressure of 11.8%, rate pressure product of 22.4% was observed after 1 min of laryngoscopy and intubation. Which is statistically significant in all hemodynamic parameters. Conclusion: This study concludes that in patients with no drugs to attenuate the sympathetic response to laryngoscopy and intubation the maximum raise in heart rate, systolic, diastolic and mean arterial blood pressures were statistically and clinically very highly significant and can be detrimental in high risk patients.

Authors and Affiliations