EFFECT OF HELICOBACTER PYLORI RELATED GASTRITIS ON THE RISK OF METABOLIC SYNDROME
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2019, Vol 4, Issue 7
Abstract
Evidence indicates that HP infection is also associated with metabolic syndrome. Specically, a cross-sectional study of a large population of Japanese adults evaluated the concentration of HPspeci c immunoglobulin G (IgG) and found that HP-infected subjects had a signicantly higher risk of Metabolic syndrome (Gunji et al., 2008). Also, Chen et al, found similar relationship between H. pylori and metabolic syndrome. The underlying mechanisms of the metabolic syndrome-HP relationship remain unknown, although chronic inammation is presumed to play a key role. Specically, HP infection induces chronic gastritis and local chronic inammation, stimulating the production of response inammatory proteins and cytokines such as C-reactive protein, tumor necrosis factor alpha (TNF-a), interleukins (IL-1, IL-6, IL-8, IL-10), and eicosanoids (D'Elios and Czinn, 2014). As overexpression of these proteins contributes to the pathogenesis of Metabolic syndrome, therefor the risk of Metabolic syndrome is expected to be affected by the inammatory burden associated with HP infection
Authors and Affiliations
Ahmed Waheed Ahmed, Hisham Abd Elhaleem Ali, Mohammed Elsayed Abdel Aal Shatat, Heba Mohammed Tawfik
Keywords
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