Effect of HIV Infection and Antiretroviral Therapy on Lipid Profile of HIV Subjects in Warri, Delta State, Nigeria
Journal Title: International Journal of Medical and Health Sciences - Year 2015, Vol 4, Issue 3
Abstract
This work was designed to study the impact of HIV infection and anti-retroviral therapy on the lipid profile of HIV patients attending Voluntary Counselling and testing centre at Government Hospital and Sage Clinic, Warri. Two hundred and fifty three subjects comprising; 85 HIV patients on ART, 90 HIV patients not on ART and 78 age-matched apparently healthy HIV negative controls were recruited for the study. Subjects were of both sexes within the age range of 18-60years. Informed consent was obtained from all participants. Ethical approval was obtained from the ethics committee of Delta State Hospital Management board. Total cholesterol, high density lipoprotein-cholesterol and triglyceride were evaluated using routine enzymatic colorimetric kits while low and very low density lipoprotein were extrapolated using Friedewald’s formula. SPSS version 21 was used for statistical data analysis. Total cholesterol (T-Chol), triglyceride (TG), low density lipoprotein (LDL)-cholesterol, very low density lipoprotein (VLDL)-cholesterol were significantly higher in HIV-positive subjects on ART and those not on ART compared to the controls (p<0.05). No significant difference was observed in the high density lipoprotein (HDL)-cholesterol in these groups (p>0.05). VLDL-C and TG was significantly higher in female control subjects than the male controls (P<0.05), while there was no significant gender difference in all the parameters in HIV positive on ART and those not on ART. HIV and ART affects lipid metabolism of HIV-positive patients as inappropriate increased serum cholesterol and triglyceride could be as a result of HIV infection which is aggravated with ART. However, it seems that neither HIV nor ART affects the level of high density lipoproteincholesterol. Therefore, HIV-positive subject should be assessed periodically for lipid profile before enrolment for HAART and during therapy given the high incidence and risk of cardiovascular disease.
Authors and Affiliations
Ifeanyichukwu, Martin Ositadinma, Osakue, Stanley Ikponmwosa, Chukwuanukwu Rebecca C. , Okeke Chizoba Okechukwu, Nworie, Amos
Keywords
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