Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study
Journal Title: International Journal of Medical Science and Public Health - Year 2015, Vol 4, Issue 1
Abstract
Background: Anemia is one of the major public health problems in the developing countries. More than 70% of pregnant women in Southeast Asian region have nutritional anemia, which affects both the mother and the newborn and subsequent child and later adult. Objective: To evaluate the response and effect of parenteral iron sucrose complex therapy in iron-de fi ciency anemia in pregnancy. Material andMethods: A prospective observational study was conducted at VS General Hospital, Ahmedabad, Gujarat, India, from September 2009 to November 2011. A total of 75 Antenatal women, between 26 and 32 weeks of pregnancy with hemoglobin level between 5 – 9 g%, were selected for study by purposive sampling. They were given intravenous iron sucrose complex in a dose of 200 mg (2 ampoules of 5 ml each) in 100 mL normal saline for 15 – 20 minutes, on alternate day. Repeat complete blood count was done after 6 weeks. Results: Of 75 women, 36 (48%) were in age group of 20 – 24 years and 49 (65.2%) were 27 – 29 weeks pregnant. The mean hemoglobin level increased from 7.8 ± 0.61 to 10.1 ± 0.73 g% ( p o 0.001) after 6 weeks of therapy. There was signi fi cant rise in mean corpuscular volume levels (from 67.8 ± 5.0 to 79.2 ± 2.3 fL; p o 0.001). 91% of patients treated for anemia delivered at full term, either vaginally (65.33%) or by lower segment cesarean section (25.3%). Most of the delivered babies (80%) had birth weight of more than 2.5 kg. No major side effects or anaphylactic reactions were observed in the women during the study period. Conclusion: Parenteral iron therapy was effective in increasing hemoglobin levels and other hematological parameters in pregnant women with moderate-to-severe anemia. If used in time, this treatment will certainly help to reduce the risk of maternal and fetal complications as well as to reduce the risk of blood transfusion during peripartum period.
Authors and Affiliations
Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati
Keywords
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- EP ID EP163912
- DOI 10.5455/ijmsph.2015.100920145
- Views 69
- Downloads 0
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