Effect of Ipomoea staphylina leaves on Streptozotocin- Nicotinamide Induced Type-II Diabetes in Wistar Rats
Journal Title: Asian Pacific Journal of Health Sciences - Year 2016, Vol 3, Issue 3
Abstract
The aim of the present study was to evaluate the antidiabetic activity of Ipomoea staphylina (IS) leaves in Streptozotocin (STZ)-nicotinamide induced type-II diabetic in rats. Oral administration of ethanolic extract of IS leaves and its fractions at the doses of 100 mg/kg and 200 mg/kg was studied in glucose-loaded and STZ-nicotinamide induced diabetic rats. The effects of extract and its fractions on blood glucose, body weight, lipid profile, plasma enzymes (SGOT, SGPT and ALP), serum urea, creatinine, total protein, liver glycogen, and activities of SOD, CAT and GPx in diabetic rats were analyzed. The IS extract and its fractions significantly reduced the blood glucose level in glucose-loaded rats. After treatment with IS extract and its fractions (100 and 200 mg/kg) for 21 days there was a significant decrease in blood glucose, total cholesterol, triglycerides, LDL-C, VLDL-C, plasma enzymes (SGOT, SGPT and ALP), serum urea, creatinine and significant increase in body weight and total protein levels was observed in treated diabetic rats. The activities of antioxidant enzymes SOD, CAT and GPx were also inceased in diabetic mice after the treatment with IS extract and its fractions. Histological analysis showed improvement in the cellular architecture of pancreas, liver and kidney.
Authors and Affiliations
S M Firdous
Keywords
Related Articles
- EP ID EP524495
- DOI 10.21276/apjhs.2016.3.3.6
- Views 142
- Downloads 0
Comparative evaluation of lichtenstein tension free hernia repair vs laparoscopic tep repair of inguinal hernia
Introduction: During the last several decades numerous innovative and creative techniques have been introduced in an effort to manage patients with inguinal hernia. Despite the development of many newer technologies incl...
Follicular carcinoma of thyroid presenting as widespread metastases
Follicular carcinoma of thyroid is the second most common thyroid carcinoma accounting for 10-20 %of all thyroid malignancies, most commonly seen above 40 years of age. Distant metastases at the time of diagnosis is 11-2...
A cross sectional study on infection control practices among mothers attending immunization clinic at a teaching hospital in Haryana
Introduction: Mother’s hand washing practices, immunization awareness and early initiation of breast feeding are important steps to reduce neonatal and infant morbidity & mortality. Still these are not routinely practice...
Chronobiology and Chronotherapy for rheumatoid arhthritis
Pulsatile drug delivery systems have been a major field of research recently. It is the most interesting time-specific and site-specific system. This system is designed for chronopharmacotherapy which is based on circadi...
Cytological evaluation of breast lesions: Can it still go the long way?
Background: Breast lesions are a common occurrence in women of all age groups. Geographically, the occurrence of non-neoplastic and neoplastic lesions varies. The accurate diagnosis of individual cases has garnered impor...