Effect of Ipratropium Inhalation on Pupil Dilatation in Rats
Journal Title: Eurasian Journal of Emergency Medicine - Year 2021, Vol 20, Issue 1
Abstract
Aim: This study aimed to investigate the effect of inhaled ipratropium on pupil diameter when applied directly to the eye in a closed environment. Materials and Methods: A total of 14, 8-week-old and 350-g weight Sprague-Dawley rats were obtained from Yeditepe University Laboratory of Experimental Animals for research. At constant temperature (22 ºC±3 ºC) and 12-hour light/dark cycle, the rats had access to standard food and water. A total of 7 rats were exposed to ipratropium, whereas 7 rats were given saline nebular. Pupil diameters and pupillary-orbital diameter ratios were compared before and 2 hours after drug exposure. Pupil diameters and pupillary-orbital diameter ratios measured before and 2 hours after ipratropium inhalation were compared in the computer environment after 4288 × 2848 pixel magnification. Results: No significant difference was observed in the pupil/orbital diameter ratios in either right or left eyes after treatment compared to baseline values (p>0.05, for both). No significant difference was found in Delta rates. The numerical data fitted the normal distribution. Conclusion: In our study, no significant difference was determined in diameter changes that would advocate a more careful action in the case of anisocoria development in patients receiving ipropropium treatment and perform a detailed neurological examination and request neurology consultation as soon as possible. Anisocoria or changes in pupil diameters encountered in both pupils may not always be associated with drug use.
Authors and Affiliations
Hatice Şeyma Akça, Büşra İhtiyar, Kamil Kokulu, Abdullah Algın, Serdar Özdemir, Serkan Emre Eroğlu, Gökhan Aksel
Keywords
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- EP ID EP693161
- DOI 10.4274/eajem.galenos.2020.29494
- Views 108
- Downloads 0
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