EFFECT OF ISOMETRIC HAND GRIP ON HEART RATE VARIABILITY IN NORMOTENSIVE HEALTHY OFFSPRING OF HYPERTENSIVE PARENTS
Journal Title: International Journal of Basic and Applied Physiology - Year 2014, Vol 3, Issue 1
Abstract
Background and objectives: One of the primary pathologies associated with hypertension is a complex autonomic malfunction with evidence of sympathetic hyperactivity and/or vagal withdrawal. The goal of present study was to assess the possibility for early detection of essential hypertension in the subjects with genetic predisposition on the basis of analysis of effect of Isometric Hand Grip (IHG) and heart rate variability. Methods: 45 young, normotensive male offspring of normotensive parents (control group) and 45 young, normotensive male offspring of hypertensive parents (test group) of similar body mass index participated in this study. Heart rate variability was recorded at baseline, during Isometric hand grip and after 5 minutes after isometric hand grip. Results: There was no significant difference in baseline parameters of heart rate variability in both groups. Low frequency in normalised unit (LFnu), Low frequency/ High Frequency (LF/HF) ratio were significantly increased and High frequency in normalised units (HFnu) was significantly decreased during isometric hand grip in test group. HFnu was significantly decreased during recovery in test group. Conclusion: Finding first indicates hyper responsiveness of sympathetic nervous system to isometric hand grip. Finding second indicates reduced vagal reactivation on recovery from isometric hand grip in test group. These results indicate the early existence of malfunctions in both branches of autonomic control in individuals at increased risk of hypertension
Authors and Affiliations
N Gupta, K Gupta
Keywords
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