EFFECT OF LACOSAMIDE ON BEHAVIOUR OF CHILDREN WITH REFRACTORY PARTIAL EPILEPSY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: A unicentre, prospective study was carried out to investigate the behavioral effects of lacosamide as adjunctive therapy with refractory partial epileptic children in tertiary care hospital with prior approval from the Institutional Human Ethical Committee.Methods: Seventy nine patients (age 5- 15 years) with refractory partial epilepsy patients were enrolled after fulfilling the inclusion and exclusion criteria. And those who had failed ≥ 2 antiepileptic drugs in whom lacosamide was added as add on drug therapy. Lacosamide tablets was administered orally twice daily. Influence of Lacosamide on children’s behaviour was performed at every visit of titration, maintenance period and 2 follow ups at monthly interval. Patient’s caregiver or investigator observed adverse events were recorded.Results: Out of 79 patient’s, 53 were males and 26 females. Patients completing 3 months, of study therapy showed significant (p<0.001) decrease in frequency of seizure and improvement in behaviour at end of the treatment period and few patients had mild transient adverse events. Three patients were dropped from the study.Conclusion: Lacosamide signifies a beneficial drug that is effective and concurrently improved patient’s behaviour in refractory partial epilepsy paediatric patients.Keywords: Inclusion, Behavior, Prospective study, Lacosamide, Influence.
Authors and Affiliations
Ismail Pasha, Mahesh Kamate, D. K Suresh
Keywords
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