Effect of latanoprost on open angle glaucoma
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 11, Issue 6
Abstract
AIM: To explore the effect and mechanism of latanoprost on open-angle glaucoma. <p>METHODS: Totally 100 patients with open angle glaucoma who had been seeking treatment in our hospital between August 2015 and August 2017 were selected as the research subjects. These patients were divided into an observation group and a control group according to the random table method, with 50 cases in each group. The control group was treated with timolol maleate eye drops, 1 drop per time, 2 times a day, treated consecutively for 12wk. The observation group was given latanoprost eye drops for treatment, 1 drop per time, 1 time a day, for a continuous treatment of 12wk. The IOP, ocular hemodynamics, visual field defects and adverse reactions in the two groups were compared. <p>RESULTS: Before treatment, there was no statistically significant difference found on the intraocular pressure between the two groups(<i>P>0.05</i>); at 4, 8, 12wk after the treatment, the intraocular pressure at different time points in the observation group was shown to be lower than that in the control group, where the difference was statistically significant(<i>P<0.05</i>). There was no statistically significant difference shown in the artery hemodynamics indexes of CRA and PCA before and after treatment in the control group(<i>P>0.05</i>); the indicators of EDV and PSV of CRA, PCA indicators in the observation group significantly increased, while the RI index decreased significantly, with the difference being statistically significant(<i>P</i><0.05). Before treatment, there was no statistically significant difference in all of the visual field defects between the two groups before treatment(<i>P>0.05</i>); after treatment, however, the scope of visual field defects was shrunk in both groups, with changes in the observation group more significant than the control group, and the difference was statistically significant(<i>P<0.05</i>)There was no statistically significant difference registered in the incidence of adverse reactions between the two groups(<i>P>0.05</i>). <p>CONCLUSION: For patients with open angle glaucoma, latanoprost eye drops is with significant curative effects and of relatively high value, which can significantly reduce the intraocular pressure, improve the ocular hemodynamics, and reduce the scope of eye damage with high safety.
Authors and Affiliations
Min Zhang
Keywords
Related Articles
- EP ID EP558518
- DOI 10.3980/j.issn.1672-5123.2018.6.20
- Views 108
- Downloads 0
Clinical observation of mitomycin and 5-fluorouracil with adjustable sutural trabeculectomy for glaucoma
AIM: To take a contrastive analysis of glaucoma patients' clinical prognosis and complications after the usage of mitomycin(MMC)or 5-fluorouracil(5-FU)combined with adjustable sutural trabeculectomy. <p>METHODS: Retrospe...
Evaluation of the ocular surface in the patients after strabismus surgery
AIM: To evaluate the ocular surface in the patients after strabismus surgery. <p>METHODS: One hundred and eighty-eight hospitalized patients(240 eyes)with strabismus from May 2015 to October 2016 in Aier Hospital were di...
Comparison of IOP detected by three kinds of tenonometers in children with high intraocular pressure and their relations with corneal thickness
AIM: To investigate the central corneal thickness(CCT)distribution of the children with ametropia in the non-contact tonometry(NCT), and the different intraocular pressure(IOP)measurements with Goldmann applanation tonom...
Clinical significance of changes of chemokine MIP-1 alpha and MIP-1 beta levels in peripheral blood of patients with diabetic retinopathy
AIM: To observe the changes of chemokine macrophage inflammatory protein(MIP-1α)and MIP-1β in peripheral blood of patients with diabetic retinopathy and to analyze its clinical significance. <p>METHODS: The patients with...
Effect of transplanted PEDF-hUCMSCs in the treatment of retinitis pigmentosa in rats
AIM: To investigate the effect of transplanted pigmented epithelium-derived factor(PEDF)on human umbilical cord-derived mesenchymal stem cells(hUCMSCs)in the treatment of retinitis pigmentosa in rat models. <p>METHODS: T...