EFFECT OF LEPTADENIA HASTATA HEXANE LEAF EXTRACTS AGAINST HEAMOTOLOGICAL, BIOCHEMICAL AND INDOMETHACIN INDUCED ULCER IN RATS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 5
Abstract
Objectives: This study was targeted at valuing a claim by traditional herbal practitioner that the leaves of Leptadenia hastata possess ulcer healing property by assessing the effect of Leptadenia hastata on ulcer induced rats. Material and method: The effects of an hexane leaf extracts of Leptadenia hastata were studied in 40 white albino rats over a period of 21days, to ascertain the claim of Leptadenia hastata has ulcerogenic properties, the rats were divided into eight groups those in group one served as control group, group two negative control (Indomethacin) ulcer induced with no treatment, while group three positive control (Omeprazole) and groups four to eight are dosed groups ranged from; 100mg/kg 200mg/kg, 300mg/kg, 400mg/kg and 500mg/kg extracts respectively, Microscopic examination was carried out and scored for the presence of lesion. The length and breadth of the lesion of the stomach was measured for ulcer index. Stomach and Blood sample were collected for Histological, hematological and biochemical analysis. The specimen of the stomach was taken for histopathological studies. Results: The study showed that the extracts of Leptadenia hastata caused increased in the weight of the rats compared to the negative control and the levels of packed cell volume, hemoglobin concentration, red blood cell, white blood cell, mean corpuscular volume and mean corpuscular hemoglobin. The changes in the biochemical parameter were all within the range of the control. Histologically, stomach degeneration was characterized by lesion and decrease number of lining cell of the epithelium. Conclusion: The study indicate that hexane leaves crude extracts of Leptadenia hastata possess ulcer healing activity.
Authors and Affiliations
Isaac John Umaru
Keywords
Related Articles
- EP ID EP637263
- DOI -
- Views 122
- Downloads 0
THE FREQUENCY OF COMPLEX FACIAL CLEFT AMONG PATIENTS PRESENT WITH OROFACIAL CLEFT
Clefts of the upper lip and palate are the most common major congenital craniofacial malformation. Clefting of the facial structure (complex facial cleft) other than the typical nasolabial region is rare. The aim of this...
SWADDLING A NEWBORN MYTHS & REALITIES
In many cultures around the world newborn babies are swaddled to help them settle and fall asleep. Parents are in need to be warned about the risks and after effects of wrapping their little ones too tight. Although the...
ANTIBACTERIAL ACTIVITY OF ETHANOLIC ROOT EXTRACTS OF UVARIA CHARMAE ON STAPHYLOCOCCUS AUREUS
Many different medicinal plants have been utilized in the treatment of infections caused by Staphylococcus aureus due to the increased antibiotic resistance exhibited by this organism. One of such medicinal plants is Uva...
INTRANASAL MIDAZOLAM, FENTANYL AND DEXMEDITOMITIDINE AS A PREMEDICATION IN PEDIATRIC SURGICAL PATIENTS
Background: For providing premedication to pediatric surgical patients, various drugs and many routes have been studied. Intranasal route is one of them. It’s one of the preferred routes because of the ease of administra...
ANTIFUNGAL ACTIVITIES OF AN EXTRACT AND CREAM FORMULATION OF COLA MILLENII K. SCHUM. IN DERMATOPHYTE-INFECTED WISTAR RATS
Objective: Cola millenii K. Schum (Malvaceae) bark have found use in traditional medicine for the treatment of skin infections such as ringworm and scabies. The present study aimed to evaluate the In vitro and In vivo an...