Effect of licofelone against mechanical hyperalgesia and cold allodynia inthe rat model of incisional pain.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 3
Abstract
Hyperalgesia from an incisional pain is evoked by noxious stimuli (mechanicaland cold). The present study was aimed to examine the effect of licofelone, a dual inhibitor of cyclooxygenases(COX-1/COX-2) and 5-lipoxygenase (5-LOX) against mechanical hyperalgesia and cold allodynia in the ratmodel of incisional pain. Mechanical hyperalgesia and cold allodynia was assessed employing Randall andSellitto analgesymeter and cold water maintained at 10 degrees C, respectively. Zileuton (25-100 mg/kg,po), a 5-LOX inhibitor, indomethacin (1-30 mg/kg, po), a non-selective COX inhibitor, and licofelone(10-100 mg/kg, po) a dual inhibitor, significantly reversed the mechanical hyperalgesia and also causedan increase in cold allodynia threshold with different pharmacologic profile. The rank order of potencybased on ED(50) values in both the paradigms was found to be licofelone > indomethacin > zileuton. Theresults of the present study are indicative of the role of leukotrienes along with prostaglandins inthe rat model of incisional pain (a paradigm of postoperative pain). The results suggested that dualinhibition approach of simultaneous inhibition of COX and LOX pathways might prove beneficial in combatinghyperalgesia of postoperative pain.
Authors and Affiliations
Vijay Singh, Chandrashekhar Patil, Shrinivas Kulkarni
Keywords
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