EFFECT OF LIPIDS ON PHYSICOCHEMICAL PROPERTIES OF LETROZOLE LOADED SOLID LIPID NANOPARTICLES
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2016, Vol 8, Issue 5
Abstract
The objective of the current investigation was to prepare solid lipid nanoparticles (SLNs) from different lipids and to study the effect of lipids on physicochemical characteristics of letrozole loaded SLN. In order to prepare small, stable, uniform and high Letrozole loaded SLNs, many factors such as lipid and stabilizer concentration and preparation parameters can be considered. Out of these, we have selected solid lipid as lipid matrix to investigate an effect on SLNs. SLNs were prepared using different lipids by modified hot sonication method. The effect of different lipids and stabilizers on physicochemical characteristics of Letrozole loaded SLNs were investigated. Letrozole loaded SLNs showed different physicochemical properties and release profiles according to used solid lipid. In case of particle size, SLN1 showed biggest particle size (532.5 ± 26.4nm) and highest encapsulation efficiency (81.37 ± 6.72%) and, SLN4 showed highest cumulative drug percentage (89.4 ± 1.8%, 24 h) release. These results suggest that lipids type affect physicochemical properties and release profile of SLN. The choice of lipid and stabilizer played important role on the physicochemical characteristics and in vitro release of Letrozole loaded SLNs.
Authors and Affiliations
Archana Nerella, Basava Raju Dontamsetti, Aruna Devi Mantena
Keywords
Related Articles
- EP ID EP625196
- DOI 10.25004/IJPSDR.2016.080501
- Views 92
- Downloads 0
BLOCKADE OF EPIDERMAL GROWTH FACTOR RECEPTOR, CYCLOXYGENASE-2 (COX-2) AND MAMMALIAN TARGET OF RAPAMYCIN (M-TOR) IN ANIMAL MODEL OF LUNG CANCER
To explore the effectiveness and possible toxicity of the use of epidermal growth factor receptor inhibitor (EGFR Inhibitor), Celecoxib (COX2 inhibitor) and Sirolimus (m-TOR inhibitor) as single agents and drug combinati...
BACTERIOLOGICAL SCREENING OF PAEDIATRIC COUGH SYRUPS MARKETED WITHIN PORT HARCOURT METROPOLIS, SOUTH-SOUTH NIGERIA
Non-adherence to good manufacturing practice alongside improper handling during dispensing, packaging and inadequate post-marketing surveillance of pharmaceutical products accounts to product’s deterioration reduced ther...
EVALUATION OF ANTI-ULCER ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACT OF WHOLE PLANT OF CLITORIA TERNATEA IN ALBINO WISTAR RATS
The objective of the present study was to evaluate antiulcer potential of aqueous and ethanolic extract Clitoria ternatea in different experimental induced ulcer models in rats. In the present study different extracts [e...
Effect of Ethanolic Extract of Fruits of Eriobotrya japonica on Lipid Profile and Body weight in Streptozotocin Induced Diabetic Rats
Eriobotrya japonica locally called as loquat in Kashmir has been studied in various parts of the world but little work has been reported on Kashmiri loquat. The chemical nature of fruits and vegetables offers a great div...
EFFECT OF PHOSPHATASES ACTIVITY IN THE HEPATOPANCREAS AND MUSCLE OF THE FRESH WATER FEMALE FIELD CRAB, SPIRALOTHELPHUSA HYDRODROMA (HERBST) TREATED WITH CYPERMETHRIN
The fresh water field crab, Spiralothelphusa hydrodroma is an important human food source in parts of South India and the crab is constantly exposed to pesticides, which are used extensively to control agricultural pests...