Effect of liver diseases on hormonal and biochemical parameters in Wistar albino rat
Journal Title: Journal of Veterinary Medical Research - Year 2018, Vol 25, Issue 1
Abstract
The current study was performed to evaluate the effect of acute and chronic hepatotoxicity induced by paracetamol and thioacetamide respectively on serum hormonal levels and biochemical parameters. Female Wistar albino rats were divided into 3 equal groups (C), (P) and (T). Group (C) were kept as control, group (P) were received paracetamol orally (500 mg/kg b.wt) daily for 15 days and those of group (T) were injected thioacetamide (200 mg/kg b.wt) intraperitonialy twice/ week for 90 days. In P group, results revealed significant elevation in liver enzyme activities (ALT, AST and ALP), T4, insulin (7th day), estrogen (7th and 15th days), triglycerides (7th day) and cholesterol levels throughout the experiment while serum proteins and T4 (15th day) showed significant decreased values. Whereas, at 90th days of chronic intoxicated group (T) resulted in significant elevation in liver enzyme activities (ALT, AST and ALP), bilirubin, estrogen, T4, triglycerides (60th and 90th days) and T3 (120th day). While the levels of T4 and cortisol (60th day), serum total protein, albumin, globulin (90th day) and insulin (120th day) showed significant decreased values when compared to control group. In conclusion, both paracetamol and thioacetamide cause different degrees of damage in liver of rats leading to clear changes in their hormonal and biochemical profiles.
Authors and Affiliations
Amira, H. Mohamed, Kamal, H. H. , Walaa, M. S. ahmed, Hanan, E. Saeed
Keywords
Related Articles
- EP ID EP658266
- DOI -
- Views 260
- Downloads 0
Development of an interactive three-dimensional virtual skeleton of birds for use in anatomical education.
The aim of the present work was to describe the way of creating chosen interactive and animated three-dimensional anatomic virtual models of particular parts of birds' skeleton. These models can be used for teaching purp...
Light and electron microscopic studies on some lymph nodes of the adult one-humped camel (Camelus dromedarius)
Samples from medial retropharyngeal, superficial cervical and deep femoral lymph nodes of four camels were fixed in neutral buffered formalin and prepared for light and electron microscopic examination. The camel lymph n...
Some anatomical studies on the arterial supply and venous drainage of the tail of the buffalo "Bos Bubalis L."
Twenty tails of buffaloes were used in this study from apparently healthy adult animals. They are dissected to reveal their arteries and veins. Fourteen photographs illustrated the results in the study. The study reveale...
Direct detection and identification of mycobacteria in bovine samples by PCR assay
Bovine tuberculosis, caused by Mycobacterium bovis, is a zoonotic disease causing approximately 6% of total human deaths. Its economic losses are not only a reduction of 10-20% in milk production and weight, but also inf...
Molecular and pathological studies of duck hepatitis virus in Egypt
Duck Hepatitis virus (DHV) causes great economic losses in waterfowl industry worldwide. 3D gene, lies in the P3 segment of the picornavirus genome, is highly conserved and is a non-structural polyprotein gene, its encod...