Effect of Losartan in Comparison with Pioglitazone on Lipid Profile in a Rat Model of Type 2 Diabetes Mellitus
Journal Title: Journal of Islamabad Medical and Dental College - Year 2018, Vol 7, Issue 1
Abstract
Objective:To evaluate the effect of losartan in comparison with pioglitazone on lipid profile in a type 2 diabetic rat mode.Materialsand Methods:This case control study was conductedin Postgraduate Medical Institute (PGMI), LahorefromJune to August 2011. Forty-five Sprague-Dawley rats of 5 weeks of age were randomized into three groups. All the rats were fed a high fat and sucrose diet. Pioglitazone or Losartan were given along with this diet to the rats in groups HFD-PIO and HFD-LOS respectively, while group HFD was kept as control. At the end of 12 weeks, serum samples were obtained from all the animals and total cholesterol, HDL-cholesterol and triglyceride levels were obtained using kit method. LDL-cholesterol was determined using the Friedewald formula.Results:At the end of study period, lipid profile parameters were statistically improved between HFD-PIO and the control HFD group. The difference in the lipid profile parameters between the HFD-LOS and the control HFD group as well as between the HFD-PIO and HFD-LOS groups was not significant.Conclusion: The ARB losartan has a small but insignificant effect on lipid profile
Authors and Affiliations
Muhammad Nauman Shad
Keywords
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