Effect of low dose aspirin therapy during period of placentation on maternal and neonatal outcome
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 6
Abstract
Background: Pre-eclampsia is a multisystem disorder usually associated with raised blood pressure and proteinuria. A relatively common complication of the second half of pregnancy, it affects 2-8% of pregnancies. The role of low-dose aspirin in the prevention of pre-eclampsia has gained attention in recent time. Aims and objectives: To study the effect of low dose aspirin therapy on maternal and neonatal outcome used during period of placentation for prevention of preeclampsia. Materials and Methods: Total 200 pregnant women with 8 to 14 weeks of gestation visiting the institute for antenatal care were selected for the study and were divided in to two groups containing 100 subjects each. Asprin group: 100 patients with aspirin between 8 to 14 weeks when maximum trophoblastic invadary activity is present. Control group: 100 patients without aspirin between 8 to 14 weeks when maximum trophoblastic invadary activity is present. The detail clinical evaluation of all the selected pregnant women was conducted. The collected information was recorded on a prestructured proforma. Regular follow up all the pregnant women was maintained till the termination of pregnancy. The maternal and fetal outcome of pregnancy was recorded. Results: Majority of the women in the present study were in the age group of 20-25 urs followed by 25-30 yrs of age and majority of the women were multi gravid. In aspirin group 3% females developed Pre-eclampsia, 1% females developed severe Pre-eclampsia, no female developed eclampsia. In control group 14% pt. developed Pre-eclampsia, 3% developed severe Pre-eclampsia, 1 patient developed eclampsia. In Aspirin group 69% deliveries occurred spontaneously whereas in control group 59% deliveries occurred spontaneously. In asprin group 90% pregnancies delivered at term in control group 77% pregnancies delivered at term. In aspirin group 1 patient had Abruption where as in Control group 4 patient had Abruption and placenta praevia in 3 patients. In Aspirin group 6 babies were Low Birth Weight and 4 were Very Low Birth Weight. In control group 20 were Low Birth Weight and 5 were Very Low Birth Weight. The incidence of neonatal mortality was 4% in Aspirin group, 8% in Control group. The maternal morbidity on the present study was zero. Conclusion: Thus we conclude that by the use of low dose aspirin during period of placentation decreases the incidence of pre-eclampsia. There was a definite decrease in the incidence of caesarean section. Significant decrease was found in the incidence of still births. Incidence of low birth weight was reduced and incidence of perinatal mortality was reduced subsequently, with use of low dose aspirin during period of placentation.
Authors and Affiliations
Vinit Ramesh Dhadke, Sanjay B Bansode, Shailesh P Vaidya
Keywords
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