EFFECT OF MANGOSTEEN EXTRACT ON NEUROINFLAMMATION IN RAT MODEL OF ACUTE TRAUMATIC BRAIN INJURY
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 3
Abstract
Objective: Traumatic brain injury (TBI) is one of the major health problems regarding morbidity and mortality, especially in productive ages. Following primary injury, there is a secondary insult, resulting in oxidative stress, neuroinflammation, and cell death. Mangosteen is a powerful natural antioxidant and anti-inflammation that also has neuroprotective property. The aim of this study was to explore the effect of mangosteen extract (ME)on neuroinflammation following TBI. Methods: A total of 30 Sprague-Dawley rats were randomized into three treatments group, i.e., sham-operated controls, closed head injury (CHI), and treatment group. In the treatment group, we gave ME once daily every day after CHI for 7 days. As oxidative process marker, we investigated malondialdehyde (MDA) expression. As neuroinflammation marker, we investigated glial fibrillary acidic protein (GFAP) and CD-68. Results: TBI increased the expression of GFAP and CD-68, but not MDA. There was significant GFAP expression difference between treatment group and CHI group. Regarding the expression of CD-68 and MDA, there was no significant difference between treatment and CHI group. Conclusion: Mangosteen extract supplementation decreased GFAP expression significantly after TBI.
Authors and Affiliations
ANDRE MAROLOP PANGIHUTAN SIAHAAN, SARMA LUMBANRAJA
Keywords
Related Articles
- EP ID EP603826
- DOI -
- Views 127
- Downloads 0
IMMUNOLOGICAL STUDY OF CORONARY ARTERY DISEASE ASSOCIATED WITH DIABETES MELLITUS TYPE II IN IRAQI PATIENTS
Objective: The objective of this study was to investigate the association between proinflammatory cytokines in special, the interleukin-6 (IL-6), and insulin-like growth factor (IGF-1) levels in coronary artery disease (...
AN UPDATE ON PHARMACOLOGICAL PROFILE OF BOSWELLIA SERRATA
Boswellia serrata (Burseraceae) is the most ancient and respected herbs in Ayurveda. In Unani system of medicine, oleo-gum resin of Boswellia serrata named Kundur played a prime ingredient role in modern quality perfumes...
PRESCRIBING PATTERNS OF ANTIBIOTICS IN PAEDIATRICS FOR RESPIRATORY TRACT INFECTIONS/ DISORDERS IN TERTIARY CARE HOSPITAL
ABSTRACTObjectives: The main objective was to study the prescribing practice of antibiotic in hospital in-patient is to assess the prescribing patternsof antibiotics in children who were admitted in a tertiary care hospi...
TASTE ALTERATION AND QUALITY OF LIFE OF PATIENTS RECEIVING CHEMOTHERAPY
Objective: The study was conducted with the aim to determine the taste alteration (TA) and its relation with quality of life (QOL) of patients receiving chemotherapy. Methods: The present study was undertaken among 100 p...
ASSOCIATION OF SERUM URIC ACID AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT DIABETIC RETINOPATHY
Objectives: Diabetic retinopathy (DR) is one of the microvascular complications in type 2 diabetes (T2D). Â Elevated serum uric acid (SUA) has been shown to play a significant role in diabetic neuropathy and nephropathy...