Effect of Masfon-Aloe vera Drink on Intestinal Motility and Transit in Wistar Albino Rats
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 6
Abstract
The effect of Masfon-Aloe vera drink on intestinal transit and motility was investigated in this study. Thirty (30) albino Wistar rats were divided into 2 batches of 15 rats each, batch 1 for intestinal motility, and batch 2 for intestinal transit experiments. Each batch was further divided into three groups of 5 rats each (control, low dose and high dose). All groups were fed with normal rat chow and water for 21 days. In addition, the control received 0.3 ml of normal saline (0.9% NaCl solution) while the low dose (LD) and high dose (HD) experimental groups received Masfon Aloe vera drink (1 ml and 3 ml/kg body weight orally, once daily respectively). The study was carried out at the Department of Physiology, University of Calabar, Nigeria. At the end of the study duration, intestinal motility and transit studies were conducted. Result for intestinal motility showed the extract (Masfon-Aloe vera drink), at either low or high dose did not significantly change the frequency and amplitude of the spontaneous contraction (basal contraction) of the rat ileum when compared with the control. Graded concentrations of Acetylcholine (10-8 to 10-4) was observed to produce a dose dependent increase in contraction of the rat ileum which was significantly (p<0.001) greater in the LD and HD groups at lower concentrations of 10-8 and 10-7M. The mean percentage intestinal transit which was not significantly different (p = 0.226, p=0.892) among the groups was 42.16 ± 2.63 in the low dose, 37.75 ± 5.15 in the high dose groups compared to 36.91 ± 3.01 in the control. Administration of atropine produced significantly higher (p<0.01) relaxations in the LD (5.00 ± 0.41 mm) and HD groups compared with control [relaxation in mm, mean ± SEM (2.25 ± 0.25) in control vs (5.00 ± 0.41) and (10.75 ± 0.25) in LD and HD respectively]. Masfon-Aloe vera drink administered at these concentrations “did” not significantly alter the basal motility and transit of the rat ileum, but was observed to potentiate Ach induced contraction of the rat ileum, and also “augmented” the relaxant effect of atropine.
Authors and Affiliations
Oka Victor Otu, Ikpi Daniel Ewa, Ofem Ofem Effiong, Archibong Archibong Nsa, Antai Atim Bassey
Keywords
Related Articles
- EP ID EP348603
- DOI 10.9734/BJMMR/2014/6589
- Views 72
- Downloads 0
Evolution and Exploration of Azadirachta indica in Dentistry: An Update
Despite great achievements globally in oral health of populations, dental caries and periodontal diseases are the most important oral health burdens particularly among under-privileged groups in developed and developing...
Antimicrobial Resistance Patterns of Escherichia coli Isolated from Urinary Tract Infections in the Midwestern United States
Aims: To determine the antimicrobial resistance of urinary tract infection isolates in a major metropolitan area for the purposes of tracking increases in resistance and to provide information that will help drive improv...
Blood Parameters and Spleen Histology Following Chronic Consumption of Ethanolic Extract of Costus afer Stem and Juice on Albino Wistar Rats
Aim: Costus afer is a medicinal plant used as a therapy for diabetes and hypertension. This study investigated the effect of crude ethanolic extract of Costus afer (Monkey sugar cane) stem and its juice on the histology...
One-time Exposure to General Anesthetics Alters Nociceptive Response and Nucleotide Hydrolysis in Infant Rats
Aims: The objective was to evaluate the single exposure of general anesthetics with or without a surgical procedure at postnatal day 14 (P14) on nociceptive behavioral responses. Furthermore, we evaluated ectonucleotidas...
Unusual Aggressive Radiographic Appearance of Simple Bone Cyst (A Case Report and Review of Literature)
Aim: This study reports a rare case of simple bone cyst (SBC) with a radiographic behavior similar to malignancies and a mixed internal structure in a 43 year-old woman who presented to a dental office with clinical symp...