Effect of melatonin on body weight, plasma lipid, leptin and insulin levels in high fat diet fed rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 3
Abstract
Aims and Objectives To understand the influence of melatonin on body weight, plasma lipid, leptin and plasma insulin levels. Materials and Methods A total of 36 laboratory bred male Sprague dawley rats were used for the experiment. All the baseline parameters like body weight, lipid levels and plasma leptin and insulin levels were measured. The rats were fed with high fat diet starting from day 0 till 6 weeks. These rats were divided into two groups of 18 each. Group 1 (Control) received normal saline and Group 2 (Test) received 0.4mcg/ml of melatonin via oral gavage tube daily for six weeks. After six weeks, the parameters like Total body weight, lipid profile, plasma leptin and insulin levels were again observed. The statistical analysis of data was done using students‘t’ test, one way or two way ANOVA followed by post hoc bonferroni multiple comparison tests using SPSS. P value less than 0.05 was considered to be significant. Results The average weight gain in control group fed with fat rich diet was increased by 6% but the melatonin supplementation suppressed this increase to only 1.03%. Further, melatonin supplementation also suppressed the rise in total cholesterol, LDL, triglycerides and HDL cholesterol significantly (P<0.05). Melatonin administration not only suppressed the rise but also decreased the plasma leptin and insulin levels by 32% & 18.9% respectively after six weeks. Conclusion Daily supplementation of melatonin for six weeks in Sprague dawley rats fed with high fat diet suppresses the rise in body weight, plasma lipid levels and also decreases leptin and insulin levels significantly.
Authors and Affiliations
J Lalithaa Aparna
Keywords
Related Articles
- EP ID EP413035
- DOI -
- Views 101
- Downloads 0
Hibiscus rosa-sinensis L. (Malvaceae): A Multipurpose Ornamental Plant
Hibiscus rosasinensis is a perennial ornamental woody plant, belong to Malvaceae family available throughout India. Various parts of this plant like roots, leaves and flowers have been known to possess medicinal properti...
Development of novel gastroretentive mucoadhesive pulsetile tablets for zileuton
In the present research work pulsatile drug delivery system of Zileuton tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by 30% concentrations of super disinte...
To Study the Pharmacological Effect and Beneficial Effect of Eucalyptus Globulus in Different types of Diseases
The plant Eucalyptus globulus, On the basis of study conducted on, it was found that Eucalyptus has storage of active constituent present in its parts; traditionally it is necessary to explore its importance as an excell...
Comparative evaluation of analgesic activity of SSRI and atypical antidepressant: an experimental study
Aim To assess the antinociceptive activity of some selective serotonin reuptake inhibitors (SSRI- fluoxetine, escitalopram) and atypical antidepressant (mirtazapine). Materials and methods Adult wistar albino rats were g...
Evaluation of therapeutic outcomes and non pharmacological therapy in patients with chronic tension-type headache presenting to a secondary care hospital
Chronic tension-type headache (CTTH) is defined as severe and persisting pain in the head with the pain being above the eyes behind the head and undoubtedly one of the most frustrating symptoms that physicians encounter...