Effect of Meloxicam in Management of Post-Laparotomy Pain and Inflammation with Reference to Certain physiological, Hematological and Behavioural Parameters in Local Breed Sheep
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 3
Abstract
This study was conducted from November2013 to May 2014, with the objective of evaluating the effect of meloxicam a non steroidal anti-inflammatory drug to decrease postoperative pain and inflammation with reference to certain physiological, hematological and behavioural parameters in sheep. A total of 20 sheep were equally allocated into control and treatment groups. This experimental study was conducted for 5 days of study period. The baseline values for physiological, hematological and behavioural parameters were measured and recorded on day 0. Laparotomy was performed on day 1 in both groups using standard surgical protocol. A dose of 0.5 mg/kg of meloxicam was administered in treatment group of sheep for 3 consecutive postoperative days. All study parameters were measured and recorded on day 2, 3 and 4 postoperatively. The collected data was statistically expressed as mean ± SD. The result obtained in this study showed that there were no significant changes in the mean post-operative quantitative measures in treatment group compared to its baseline value. The mean physiological parameters like rectal temperature, heart rate and respiratory rate were significantly lower (p ˂ 0.05) in treatment group compared to the control group. The mean values of these parameters were significantly reduced from day 2 to 4 post-operatively. There was a significantly (p < 0.05) lower mean percentage of hematological parameters such as total and differential leukocyte count. The major constitute of total leukocyte count in this study were neutrophil followed by lymphocyte and monocyte. The beneficial effect of administering meloxicam had significantly maintained normal behavioural parameters like feed and water intake in treatment group. The results of this study showed that meloxicam had reduced postoperative pain and inflammation in sheep.
Authors and Affiliations
Wale Tesfaye Asefa Areru
Keywords
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- EP ID EP550076
- DOI 10.22192/ijcrms.2017.03.03.006
- Views 106
- Downloads 0
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