Effect of Metaboreflex on Cardiovascular System in Subjects of Metabolic Syndrome
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 7
Abstract
Introduction: Metaboreflex is a reflex in which muscle receptors send signals regarding metabolic (metabolites accumulation like lactic acid, potassium, adenosine) conditions of the muscles to nucleus tractus solitarius via afferent III and IV fibres to cause haemodynamic adjustments in order to regulate blood flow on the basis of the status of contracting muscle. Dysregulation in its mechanism in metabolic syndrome is demonstrated. Aim: to study the effect of metaboreflex by both isometric and rhythmic handgrip exercise on CVS parameters {Blood Pressure (BP), Cardiac Output (CO) and Systemic Vascular Resistance (SVR)} in subjects of metabolic syndrome. Materials and Methods: In this study, 27 subjects aged 25 to 45 years were enrolled after ethical clearance and proper consent. They were divided into: a) subjects without metabolic syndrome; and b) subjects with metabolic syndrome. Impedance cardiovasography was done to assess cardiac parameters (systolic and diastolic blood pressure, cardiac output, systemic vascular resistance). Pre-exercise parameters were assessed followed by isometric exercise and post-isometric exercise parameter measurement. Again after rest, rhythmic exercise was followed. Finally post exercise parameters were assessed. Student paired t-test for comparison between pre and post exercise parameters were done. Results: Changes in diastolic BP following exercise were statistically significant in subjects without metabolic syndrome (p-value 0.01 and 0.001 following isometric and rhythmic exercise respectively). In subjects with metabolic syndrome also these changes were significant, but to a lesser extent (p-value 0.1 and 0.01 respectively for isometric and rhythmic exercise). Changes in systolic BP following exercise were statistically significant in subjects without metabolic syndrome (p-value 0.001 and 0.001 following isometric and rhythmic exercise respectively). In subjects with metabolic syndrome also these changes were significant (p-value 0.01 and 0.001 respectively for isometric and rhythmic exercise). Conclusion: Diminished pressor response is found after exercise in subjects with metabolic syndrome.
Authors and Affiliations
PRAMITA DUBEY, SUNITA TIWARI, MANISH BAJPAI, KALPANA SINGH, PRAVEEN JHA
Keywords
Related Articles
- EP ID EP353322
- DOI 10.7860/JCDR/2017/27583.10178
- Views 59
- Downloads 0
Situs Inversus Totalis with Chronic Respiratory Ailment in a Fertile Male
ABSTRACT Primary Ciliary Dyskinesia (PCD) is a rare ciliopathic autosomal recessive genetic disorder that causes defect in the action of cilia lining the respiratory tract. In a total of 50% cases of situs inversus total...
Hyponatremia in Patients Admitted with Stroke
ABSTRACT Introduction: Many studies have focused on association of serum electrolytes with hypertension. In recent years status of serum sodium have established an important role in the distinguishing the two entities of...
Organochlorine Pesticide-Mediated Induction of NADPH Oxidase and Nitric-Oxide Synthase in Endothelial Cell
Introduction: Organochlorine Pesticides (OCPs) are detected ubiquitously in human and have been shown to be associated with Cardiovascular Disease (CVD) and atherosclerosis. Aim: To find out the effect of organochlorine...
Enteric Fever in Two Siblings with Severe Haemorrhage and Shock
ABSTRACT Enteric fever is an infectious disease caused by Salmonella typhi, more common in developing countries. It can affect almost all organ systems of the body. There have been occasional reports in literature of pat...
Evaluation of the Physical and Mechanical Properties of Flexible Resins under the Influence of Thermocycling
Introduction: New materials are developed all the time to better suit the patients' needs, such as flexible injectable thermoplastic resins that provide more esthetics to patients using removable partial dentures. Aim: T...