Effect of metformin on thyrotropin levels in treatment-naive type 2 diabetes and related traits
Journal Title: Journal of Medical Sciences - Year 2015, Vol 18, Issue 1
Abstract
INTRODUCTION: Metformin is the drug of choice for initiating treatment in type 2 DM, recently it has been found that metformin also suppresses TSH. We also tried to study this thyroidal effect of metformin. METHODS: We recruited 72 patients, 56 of type 2 diabetes and 16 had PCOS, all subjects were treatment naive and we treated them with metformin 1000 mg and 500 mg respectively. We took samples at baseline and after 6 months of treatment, we measured thyroid functions and insulin resistance parameters both at baseline and 6 months. RESULTS: TSH decreased from a mean of 3.32±1.99 to 2.90±1.65 μIU/ml. (p = 0.07). Total T4 levels dropped 8.33±1.71 to 7.55±1.26 μg/dl, (p=0.04) There was no significant change in free T4. Change in TSH was significant only in whom HOMA IR also decreased, in these subjects TSH changed from 3.48±2.01 to 2.89±1.63; P=0.033. CONCLUSION: Metformin causes suppression of TSH levels in those subjects in whom it also causes a decrease in HOMA IR. T4 levels were also decreased probably because of altered protein binding.
Authors and Affiliations
Idrees Mubarik, Shariq R. Masoodi, Zaffar Amin Shah, Syed Mudasar
Keywords
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