Effect of methanolic extract of Alchornea cordifolia leaves on the sexual behavior of senescent and sexually inexperienced rats
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 6
Abstract
Alchornea cordifolia, a shrub found in tropical Africa, is used to treat several physiological disorders, including male infertility and impotency. The main objective of this study was to determine the effect of the methanolic extract of Alchornea cordifolia leaves on the sexual behavior of senescent and sexually inexperienced rats. In order to evaluate aphrodisiac properties and reproductive performance, rats were divided into groups: group I receiving distilled water, group II receiving testosterone, group III receiving sildenafil citrate, group IV and V receiving the methanolic extract of Alchornea cordifolia leaves at 200 mg / kg and 400 mg / kg, respectively. The treatment was done by gavage for groups I, III, IV and V and subcutaneous injection of testosterone every three days for group II for 14 days. On days 1, 7 and 14, the rats were mated to the receptive females. At the end of this last treatment, the rats were mated with gonad-intact females. 14 days after of treatment, the extract leads to an increase in libido and sexual performance parameters (mounts, intromissions and ejaculations frequency) and an increase in sexual desire (decrease of mount and intromission latency). The extract also prolonged the duration of coitus by increasing the ejaculation latency and the average interval of copulation. An increase in the percentage of female’s rats impregnated as well as the numbers of implantations were recorded in females’ rats mated with the males treated with our extract. These results reveal the potential of the methanolic extract of Alchornea cordifolia leaves to improve male reproductive performance justifying its use in traditional medicine.
Authors and Affiliations
Marie Ide Ngaha Njila, Goh Yong Meng, Mahdi Ebrahimi, Elmutaz Atta Awad, Falah Hasan Baiee, Hubert Kenmogne, Brice Landry Koloko, Magloire Hambe, Samuel Honoré Mandenguè, Dieudonné Massoma Lembè
Phytochemical screening and antibacterial properties of Garcinia kola
Extract of bark, seed and root of Garcinia kola were used to determine the antibacterial properties of the extract as well as determine which extract is most effective. Methanol and ethanol were used for the extraction...
Effect of Centella asiatica against anti-tuberculosis drugs-induced hepatotoxicity: Involvement of mitochondria and oxidative stress
The liver is an integral organ in the body and plays a vital role for the metabolism of endogenous and exogenous agents. Drug-induced liver toxicity is one of most common cause of liver injury. It accounts for approxim...
Pharmacognostical and Phytochemical Evaluation of Arka Taila gel- External dermal application
Arka Taila is an important Ayurvedic formulation containing Arka (Calotropis procera (Ait)R. Br), Haridra (Curcuma longa Linn.), Sarsapa (Brassica nigra). 15% aerosol was added in Arka Taila for obtaining Arka Taila ge...
Resistance modulation studies of vernolide from Vernonia colorata(Drake) on ciprofloxacin, amoxicillin, tetracycline and erythromycin
Resistance modulatory activities of natural products on traditional antibiotics have gained scientific interest in recent years. This is aimed at maximizing antimicrobial potency with major strides in curbing microbial...
An overview: Citrus maxima
Plants have been used as traditional medicine for several thousands of years. Herbal medicine is still a mainstay of about 70-80% of the world’s population as they are easily available source for healthcare purposes in...