EFFECT OF METHANOLIC FRACTION OF KALANCHOE CRENATA ON RENAL MORPHOPHYSIOLOGY IN ADRIAMYCIN-INDUCED IMPAIRED KIDNEY IN RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 2
Abstract
Objectives: The effect of methanolic extract of Kalanchoe crenata (MEKC) was investigated on renal morphology and function in adriamycin-induced kidney impairment in rats.Methods: Ether anesthetized rats received three intravenous injections (days 0, 14, 28) of 2 mg/kg body weight of adriamycin. Repeated doses of the extract (0, 50 and 68 mg/kg bw) and losartan (10 mg/kg bw) were administered orally once daily, for 6 weeks, to adriamycin- nephropathic rats. Kidney functions were assessed through proteinuria, creatinemia and creatinuria, renal malondialdehyde (MDA) level, superoxide dismutase (SOD) activity and morphology analyses.Results: The 50 and 68 mg/kg MEKC, as the losartan, decreased proteinuria: -63.74 % and -64.94 % respectively, significantly (P<0.01) increased the creatinuria and the creatinuria/creatinemia ratio, and also decreased the creatinemia in diseased rats. The plant extracts markedly (P<0.05) increased plasma sodium, and decreased (P<0.01) the urinary sodium and potassium levels. The MEKC has remarkably (P<0.01) decreased the level of the thiobarbituric acid reactive substances and increased the SOD level in nephropathic rats. The extract has improved the damage of kidney induced by adriamycin.Conclusion: The results indicate that the treatment with the K. crenata methanolic extract may improve proteinuria and all the symptoms that breed from nephropathy, and could improve kidney morphology. Therefore, K. crenata could be promising for the development of a standardized phytomedicine for the treatment of kidney disease.Â
Authors and Affiliations
René Kamgang, Angèle Foyet Fondjo, Jean-louis Essame Oyono
Keywords
Related Articles
- EP ID EP579041
- DOI -
- Views 55
- Downloads 0
EVALUATION OF ANTI-CML ACTIVITY OF METHANOL AND AQUEOUS EXTRACTS OF BENKARA MALABARICA (LAM.) TIRVENG PLANT LEAVES
Objective: To investigate the phytoconstituents and in vitro cytotoxicity of methanol (MeOH) and aqueous (AQE) extracts of Benkara malabarica (Lam.) Triveng (BM) plant leaves.Methods: Gas chromatography-mass spectrometry...
IN SILICO MOLECULAR DOCKING OF XANTHONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITOR AGENTS
Objective: To demonstrate the potential ofdifferent xanthone derivatives as cyclooxygenase-2 (COX-2) inhibitor agents and their selectivity against cycloooxygenase-1 (COX-1) and COX-2 using molecular simulation.Methods:...
RADICAL SCAVENGING ACTIVITY OF TRITERPENE STEROIDS FROM STEM OFPOLYGONUM PULCHRUM Bl
Objective: P. pulchrum grows abundantly in Kendari (Sulawesi Tenggara province, Indonesia).However, there is no report neither chemical contents nor biological activitiesof the plant. This project studiesthe isolation, s...
ACUTE AND SUB CHRONIC TOXICITY STUDIES OF PURIFIED WITHANIA SOMNIFERA EXTRACT IN RATS
Objective: The objective of the present study was to evaluate the acute and sub-chronic (90 d; repeated dose) toxicity of Withania somnifera (ashwagandha) extract in rats.Methods: The acute toxicity was evaluated as per...
STABILITY INDICATING UPLC METHOD FOR QUANTIFICATION OF TOLPERISONE HCL AND PARACETAMOL FROM MUSCLE RELAXANT COMBINATION TABLET
Objective: In the present work, rapid and sensitive isocratic RP-UPLC method was established and comprehensive validation study for the estimation of Tolperisone HCl and Paracetamol was carried out according to internati...