Effect of methylprednisolone treatment on expression of sPECAM-1 and CXCL10 chemokine in serum of MS patients.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 6
Abstract
In order to elucidate the mechanism of intravenous methylprednisolone (IVMP) therapy of relapses in multiple sclerosis (MS) patients, we have undertaken a study on the expression of the chemokines: soluble platelet endothelial cell adhesion molecule (sPECAM-1) and interferon gamma-inducible protein (CXCL10), before and after treatment. As more becomes known about the mechanism of methylprednisolone (MP) action, it may be possible to find a more specific treatment as well for the individual patients as the phase of the disease. The mean level of sPECAM-1 in our material was almost identical in either the MS and control subjects. After a 5-day therapy with IVMP, no changes were found in comparison with the starting value. The serum concentration of CXCL10 in MS patients was found to be higher compared to that in sera from control subjects. After therapy with IVMP the mean level of CXCL10 was diminished to the initial value and occasionally was even lower than in the control group. The findings established in our present study indicate that IVMP diminished significantly the elevated expression of CXCL10, which seems to be an important factor in the mechanism of this drug action on MSrelapses. It is important to stress that the reaction is not a general one because there was no effect on the expression of sPECAM-1.
Authors and Affiliations
Grażyna Michałowska-Wender, Jacek Losy, Adam Szczuciński, Justyna Biernacka-Łukanty, Mieczysław Wender
Keywords
Related Articles
- EP ID EP159855
- DOI -
- Views 93
- Downloads 0
Endothelial dysfunction in pre-eclampsia.
The repeated demonstration of biomarkers of endothelial cell and leukocyte activation has suggested that the maternal syndrome of pre-eclampsia arises from a generalised maternal inflammatory systemic response incorporat...
Effect of kindled seizures on rat behavior in water Morris maze test and amino acid concentrations in brain structures.
The effects of kindled seizures elicited by repeated pentetetrazole (PTZ) injections, on learning and memory in the Morris water maze test and on concentration of brain amino acids, were examined in rats. It was found th...
Tumor anti-initiating activity of some novel 3,4-dihydropyrimidinones.
Halting the tumor initiation process by targeting the inhibition of the carcinogens metabolic activators (CYP), the induction of the carcinogen detoxification enzymes (glutathione-S-transferases, GSTs), and the induction...
Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia.
The potent vasoconstrictor endothelin-1 has been implicated in the pathogenesis of plasma oxidative stress seen in sepsis. The selective endothelin receptor blockers BQ123 and BQ788 were used to investigate the importanc...
Animal models of acute renal failure.
The animal models are pivotal for understanding the characteristics of acute renal failure (ARF) and development of effective therapy for its optimal management. Since the etiology for induction of renal failure is multi...