Effect of mismatch repair genes expression in right colon cancer on pathological characteristics
Journal Title: Journal of Surgery : Concepts & Practice - Year 2021, Vol 26, Issue 1
Abstract
[Objective] To investigate the defect of expression of mismatch repair genes(MMR) including MLH1, MSH2, MSH6 and PMS2 in sporadic colon cancer, and analyze the expression of MMR related to pathological change of patients with right colon cancer. [Methods] The data of 206 patients with colon cancer including 116 cases with left colon cancer and 90 cases with right colon cancer in our hospital were collected from January 2015 to August 2020. The expression of MMR including MLH1, MSH2, MSH6 and PMS2 was detected by immunohistochemistry. The relation of defect in expression of MMR to pathological changes in colon cancer was analyzed. [Results] The rate of expression defect of MMR in patients with right colon cancer was higher than that in patients with left colon cancer. The expression defect of MMR was significantly related to tumor differentiation and neural invasion in patients with right colon cancer (P<0.05). [Conclusions] Higher rate of expression defect of MMR in patients with sporadic right colon cancer was present compared with the patients of left colon cancer. The patients of right colon cancer with expression defect of MMR have poorly pathological differentiated and are unprone to perineural invasion.
Authors and Affiliations
Wanneng YAN, Haijie MA, Chaomin SHEN
Keywords
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