Effect of Monotherapy with Atenolol and Enalapril on Lipid Profile in Pre and Postmenopausal Women with Essential Hypertension
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: Essential hypertension can be defined as disorder in which arterial blood pressure rises progressively over a period of month or year to the level at which, if sustained, leads to cardiovascular injury. In hypertensive patients, metabolic abnormalities like dyslipidemia are commonly observed. Studies have positively correlated total and low density lipoprotein cholesterol and coronary heart diseases. Also, elevated tyriglycerides are known to be common risk factors for coronary events. Reduction in mortality in hypertension and prolonged survival of patients with coronary heart diseases is observed with chronic treatment of atenolol and other ACE inhibitors like enalapril. The present study was aimed to evaluate the effect of atenolol and enalapril on lipid profile in pre and postmenopausal women with essential hypertension. Material and methods: The study included normal control group, clinically healthy premenopausal (n=30) and postmenopausal (n=30) women were selected. For the premenopausal essential hypertensive women group, first time detected essential hypertensive women with age group 20-50 years were selected (n=30) and similarly for postmenopausal group, first time detected essential hypertensive women with age group 50-70 years were selected (n=30). Half the patients from premenopausal group and postmenopausal group were treated with atenolol (10-40 mg/day) and other half with enalapril (2.5-20 mg/day) as per prescription and results were compared with normal control group. All the parameters were studied before and after treatment at the interval of 3, 6 and 12 months and comparison of the results was done with normal control of pre and postmenopausal women. Results: In the untreated group, the value of triglycerides in the pre-menopausal group was 151.2 mg/ dL while in the postmenopausal group was 155.8 mg/ dL. The value of total cholesterol in the pre-menopausal and post- menopausal group was 154.8 and 159.2 mg/ dL. On prescribing atenolol, abnormal lipid profile was observed in pre and postmenopausal hypertensive women as compared to normal control. Conclusion: Regardless of the underlying mechnaisms, metabolic defects with pathogenic potenial are altered in hypertensive patient
Authors and Affiliations
Raj Kumar Das, Vaishali R. Das, Juilee D. Sawalakhe, Shailaja R. Raghatate
Keywords
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