Effect of Muqil, Murmakki, Abhalin Polycystic Ovarian Disease associated Secondary Amenorrhoea: An observational study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Background and objectives: Amenorrhoea is not a diagnosis in itself, but rather a most common clinical sign of reproductive dysfunction and the incidence of amenorrhoea due to polycystic ovarian syndrome is 28%. The objective of the study was to evaluate the efficacy and safety of research drugs Muqil, (Commiphoramuqul), Murmakki (Commiphoramyrrha) and Abhal (JuniperuscommunisLinn) in Polycystic Ovarian Disease (PCOD) associated Secondary Amenorrhoea. Methods: A single blind non-randomized pre and post observational study was carried out at National Institute of Unani Medicine Hospital, Bengaluru. Patients (n=30) with PCOD in the age group of 18-35 years with oligo/secondary amenorrhoea were included in the study.Patients with thyroid dysfunction, hyperprolactinemia, systemic illnesses, malignancies, use of hormonal pills in last 2 months, pregnancy and lactation were excluded. Research drugs were administered orally in a dose of 6 g/day (tablet form) with water for seven days in a month for three consecutive months. Primary outcome measure (withdrawal bleeding) and secondary outcome measure (menstrual regulation) were assessed to determine the effect of research drugs. Data were analyzed using paired Student’s t-test. Results: Withdrawal bleeding was achieved in 63.33% patients, while 36.6% patients had no bleeding. Menstrual regulation was achieved in 73.33% patients; where as 26.66% had persistent irregular menstruation. Achievement in outcome measures is due to improvement in duration of cycle, which though increased in 1st cycle of treatment (P<0.001), and then decreases in subsequent cycles; highly significant reduction in BMI (P<0.001), suggestive significant change in waist circumference (P=0.064+) and absence of PCOD in 20% of patients was noted after treatment. No significant difference in hirsutism, luteinizing hormone/follicle stimulating hormone ratio and mean ovarian volume was observed during the trial. Interpretation and conclusion: Research drugs (Muqil, Murmakki, Abhal) was an effective alternate therapeutic option in patients with PCOD associated secondary amenorrhoea.
Authors and Affiliations
Dr. Rehana Khatoon, Dr. Ismath Shameem
Keywords
Related Articles
- EP ID EP244368
- DOI 10.9790/0853-1610090715
- Views 38
- Downloads 0
Arteriovenous Malformation Of The Uterus
Uterine Arteriovenous malformations (UAVM) are uncommon entities and should be considered in patients who present with profuse genital tract bleeding. There are two types of uterine AVM: acquired and congenital. Acquired...
MicroBox White light PCNL puncture trainer
Aim : To create simplest PCNL puncture trainer & understand principles of puncture PCNL Methods /Design: Two Transparent plastic boxes reformed to upper deck made of lids 3 cms apart & lower deck with bottoms glued 3cms...
Pre Menarcheal Knowledge and Some Socio- Behavioral Variables: A Community Based Comparative Study on Bengali Women
Menarche is often considered as a significant milestone in the life of a woman. However, in developing countries like India, menstruation is still recognized as a taboo which prevents adolescent girls from getting approp...
Survey on Photovoltaic Microgrid with MPPT
Improving the efficiency of MPPT is the major concern with the Photovoltaic (PV) power system. This paper reviews 18 contributions on PV power generating system under MMPT algorithm. The review follows on three categorie...
To Evaluate the Success Rate and Future Outcomes of Laparoscopic Orchidopexy Compared With Open Orchidopexy in Modern Era"
INTRODUCTION- Isolated cryptorchidism is one of the most common congenital anomalies found at birth and affects about 3% of full-term male new-borns1-3 . Once cryptorchidism is diagnosed, treatment choices may include wa...