Effect of Myristica fragrans Extract on Food Intake and Body Weight in Experimental Models

Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 2

Abstract

ABSTRACT Introduction: Myristica fragrans (Mace) is one of the commonly used Indian spices. It was used in traditional medicine to treat digestive problems, rheumatism, hyperlipidaemia, diarrhoea and insomnia. More food intake than required on a daily basis, can lead to overweight Body Mass Index (BMI 25-30) or Obesity (BMI >30). Herbal supplements and diet based therapies for weight loss are among the most common in Complementary and Alternative Medicine (CAM) modalities. Myristica fragrans (M. fragrans) contains Tetrahydrofuran (THF), Lignans. Saponins, flavonoids, glycosides, tannins and terpenoids. These chemical compounds are believed to have anti-obesity properties. Hence, Mace extract was selected to observe its effect on food intake and body weight. Aim: To evaluate the effect of M. fragrans extract on food intake and body weight in normal and obese wistar albino rats. Materials and Methods: Healthy albino rats (male/female) weighing between 150-180 gm were selected and randomly divided into five groups with six rats each. Body weight of all rats was recorded on day one. From day one to day 35 (five weeks), Body weight (BW) and Food intake (FI) capacity of an individual rat per day and for 35 days was measured in all the groups before treatment with M. fragrans extract. Group-I (Control) was treated with standard pellet diet and normal saline, Group-II (Test 1) with M. fragrans extract 200 mg/kg and Group-III (Test 2) with Myristica fragrans Extract (MFE) 400 mg/kg for 35 days (day 36 to day 70). Group IV (Test 3) and V (Test 4) were given Cafeteria Diet (CD) to induce obesity for first five weeks and last five weeks treated with M. fragrans Extract in the doses of 200 mg/kg and 400 mg/kg respectively. On day 70, FI capacity and BW of each rat was measured statistically using SPSS Statistics 20.0 (IBM software) for the analysis. Animals were observed for FI capacity and BW for 70 days (first 35 days and last 35 days). Results: Repeated measures One-way analysis of variance (ANOVA) indicated that, after 35 days of treatment (between 36-70 days), there was a significant reduction of FI capacity and BW in Group III and V, and slightly reduced in Group-II and IV in a dose dependent manner (p<0.01) but there was no difference in Group-I animals. Conclusion: These results suggest that M. fragrans extract may have clinical value in the treatment of obesity due to its inhibitory effect on FI capacity (by inhibiting hunger sensory mechanism) and BW by inhibiting pancreatic lipase enzyme.

Authors and Affiliations

Yakaiah Vangoori, Anusha Dakshinamoorthi, R Prabhakar Rao, Darling Chelathai David, K Anantha Babu

Keywords

Related Articles

Infantile Alexander Disease: Case Report and Review of Literature

Alexander Disease (AD) is an autosomal dominant leukodystrophy and occurs predominantly in infants and children. It usually results in death within ten years after onset. Among the four subtypes, infantile form comprises...

Failed Back Surgery Syndrome: Evaluation with Magnetic Resonance Imaging

Introduction: Failed Back Surgery Syndrome (FBSS) is a generalized term used to describe varied spinal symptoms of patients who have had unsuccessful results after spinal surgery. The treatment of FBSS is challenging and...

Actinomycosis Calcaneum- A Rare Case Report

Actinomyces is anaerobic, gram-positive bacilli that superficially resemble fungi and give rise to suppurative and granulomatous infection. The organisms are commensals to human body but under suitable conditions can inv...

Assessment of Serum Retinol Binding Protein 4 in Patients with Hepatocellular Carcinoma

ABSTRACT Introduction: Retinol Binding Protein 4 (RBP4) may be indirectly involved in the induction of carcinogenesis as it was identified as a key regulator of insulin resistance in obesity and diabetes. Data about ser...

Download PDF file
  • EP ID EP510146
  • DOI 10.7860/JCDR/2018/28944.11169
  • Views 54
  • Downloads 0

How To Cite

Yakaiah Vangoori, Anusha Dakshinamoorthi, R Prabhakar Rao, Darling Chelathai David, K Anantha Babu (2018). Effect of Myristica fragrans Extract on Food Intake and Body Weight in Experimental Models. Journal of Clinical and Diagnostic Research, 12(2), 1-5. https://europub.co.uk/articles/-A-510146