Effect of natalizumab on oxidative damage biomarkers in relapsing-remitting multiple sclerosis.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 3
Abstract
Background: Natalizumab is a monoclonal antibody used to treat multiple sclerosis. This study sought to determine whether the protective action of natalizumab involved a reduction in oxidative damage. Methods: Twenty-two multiple sclerosis patients fulfilling the revised McDonald criteria were assigned to treatment with 300 mg natalizumab intravenously once monthly (infusion every 4 weeks) in accordance with Spanish guidelines. Carbonylated proteins, 8-hydroxy-2'-deoxyguanosine, total glutathione, reduced glutathione, superoxide dismutase, glutathione peroxidase, and myeloperoxidase levels were measured at baseline and after 14 months' treatment, and the antioxidant gap was calculated. Results: Natalizumab prompted a drop in oxidative-damage biomarker levels, together with a reduction both in myeloperoxidase levels and in the myeloperoxidase/neutrophil granulocyte ratio. Interestingly, natalizumab induced nuclear translocation of Nrf2 and a fall in serum vascular cell adhesion molecule-1 levels. Conclusion: These findings suggest that natalizumab has a beneficial effect on oxidative damage found in MS patients.
Authors and Affiliations
Inmaculada Tasset, Carmen Bahamonde, Eduardo Agüera, Cristina Conde, Antonio Cruz, Aleyda Pérez-Herrera, Félix Gascón, Ana Giraldo, María Ruiz, Rafael Lillo, Fernando Sánchez-López, Isaac Túnez
Keywords
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