EFFECT OF NATURAL GUMS ON FORMULATION OF ORAL SUSTAINED RELEASE MATRIX TABLETS OF CHLORZOXAZONE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
The aim of the study was to prepare and evaluate the Chlorzoxazone sustained release tablets by using natural gums in order to reduce the dose frequency and to improve the patient compliance. The tablets were prepared by direct compression method using natural gums such as Acacia (F1, F2 and F3), Guargum (F4, F5 and F6) and Tragacanth (F7, F8 and F9) at different concentrations. The tablets were evaluated for weight variation, hardness, friability, thickness, drug content uniformity and in-vitro drug release. All the formulations have passed in physical characterization as per the standard limits in average weight, hardness, thickness, friability and drug content. FT-IR studies, reveals that the drug was compatible with excipients. Based on the in-vitro drug release F3, F6 and F9 showed sustained release effect up to 12 hours (98.2%, 86.4% and 91.6%). Optimized formulation F6 was subjected to stability studies for two months at 28oc and 45oc with 75±5% RH as per ICH guidelines and result does not shows any changes in physical parameters and in-vitro release studies.
Authors and Affiliations
Rajiya . Begum, MA Aleemuddin. , T Gowtham. , B Thrishala. , CH Nagaprashanthi.
Keywords
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