Effect of nicotine on platelet function
Journal Title: Medpulse International Journal of Physiology - Year 2018, Vol 5, Issue 2
Abstract
Background: Tobacco is the dried and processed leaves of the plant Nicotiana tobacum that is widely cultivated and commercially grown in many countries of the world. In India, tobacco is taken in several other forms also, for example, Pan (betel quid), dried leaves (Patti), paste (Qiwam, Zarda), tobacco with lime (Khaini/Mawa). Its use is common in various parts of the world, including India and central Asia. An increase in the consumption of tobacco has been noticed among high school students, college students, and sportspersons .This is immensely popular in all socio economic states in India. It is viewed as especially ominous because of the ease , low expense of rocurement, youth appeal, convenient shelf life and lack of social stigma. Despite the known health onsequences of tobacco chewing‖ is not viewed by users as particularly dangerous and is considered less of a ―social evil‖ than smoking by much of the public. Previous reports have described long-term harmful effects of nicotine on various body parameters.. In view of the various pharmacological actions of nicotine and additives and the wide use in many regions and countries, chronic consumption may affect the status of hematological parameters and further delineate the effects of tobacco use to health. The effect of smokeless tobacco use on health irrespective of the mode of consumption has been well documented. Objective: this study was conducted to determine ematological effects of nicotine on platelet count and its functions. Materials and Methods: This cross sectional study was done in the department of internal medicine Owaisi Hospital and Research Centre. A detailed assessment was done on 200 apparently healthy subjects, out of which 100 were tobacco chewers and 100 non chewers. Various arameters were recorded which include personal details, department of work, history of smoking , chewing tobacco, history of exposure to tobacco smoke, history of any chronic disease like diabetes mellitus and medication history. Hematological investigations done. Automated blood analyzer was used for estimation of platelet count Results: In tobacco chewers the following platelet parameters are higher than non-chewers. 1. Platelet count - Statistically significant. 2. PCT- not significant statistically.
Authors and Affiliations
Fariha Mohammedi, Mohammed Abdul Hannan Hazari, Farisa Khatoon, Kazi Husna Syed Imran Ali
Keywords
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