Effect of nitric oxide and its intracellular signal <br /> (cGMP) in the progressive motility of human sperm <br /> <br />
Journal Title: مجله دانشگاه علوم پزشکی شهرکرد - Year 2007, Vol 9, Issue 2
Abstract
Background and aim: Nitric oxide (NO), an active and non-stable compound, has been shown to regulate many sperm functions such as acrosome reaction and sperm chemotaxis. The aim of this study was to investigate the effects of NO and cGMP in the progressive motility of human sperm. Methods: After incubation of twenty normozoospermic samples for 90 minutes in the presence of ODQ (soluble guanylate cycles inhibitor), GSNO (NO donor), 8-br-cGMP (cGMP analogue) and ODQ+GSNO, the progressive motility were assessed by CASA system. Data were analyzed using paired t test. Results: Progressive motilities of sperm increased 4.1% in intubation with GSNO at min 90th (p
Authors and Affiliations
hosain Hassanpour
Keywords
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