Effect of Nyctanthes arbor tristis leaf extract against scopolamine-induced cognitive impairment in rats
Journal Title: Herba Polonica - Year 2014, Vol 60, Issue 4
Abstract
Nyctanthes arbor tristis (NATE) ethanol extract (150 mg/kg, orally) was evaluated for its protective effect against scopolamine-induced (1 mg/kg i.p.) cognitive impairments in rats using behavioral models like radial arm maze test, Morris water maze test and active avoidance test. NATE effect was evaluated and compared with the standard piracetam (200mg/kg i.p.). NATE (p<0.005) significantly reversed the impairment produced by the scopolamine in radial arm maze test. In addition, NATE also decreased the time period taken to find the hidden platform in Morris water maze test and increased number of avoidances in active avoidance paradigm. Acetylcholinesterase activity and thiobarbituric acid levels were significantly (p<0.005) decreased along with the rise in activities of superoxide dismutase and catalase. This might suggest that the NATE has protective effect against scopolamine-induced cognitive impairment in rats through acetylcholine muscarinic receptor pathway and also antioxidant activity. No significant changes were found in histopathological studies of brain.
Authors and Affiliations
Repala Anusha, Donapati Deepika, Bashetty Phanindhra, Gadiyaram Vikas, Akondi Raju
Keywords
Related Articles
- EP ID EP266788
- DOI 10.1515/hepo-2015-0003
- Views 90
- Downloads 0
Pesticidal activity of certain plant extracts and their isolates against the cowpea beetle Callosobruchus maculatus (F.) (Coleoptera: Chrysomelidae: Bruchinae)
Different extracts from seven plant species were assayed against the cowpea beetle (Callosobruchus maculatus) in the laboratory. The plants were extracted sequentially with petroleum ether, chloroform and ethyl alcohol....
Twinflower (Linnaea borealis L.) – plant species of potential medicinal properties
Twinflower (Linnaea borealis L.) is a widespread circumboreal plant species belonging to Linnaeaceae family (previously Caprifoliaceae). L. borealis commonly grows in taiga and tundra. In some countries in Europe, includ...
Chemical variability of common skullcap (Scutellaria galericulata L.) wild growing in the area of eastern Poland
Introduction. In the group of plants revealing adaptogenic activity, species belonging to Scutellaria genus are considered to be the most important ones. Common skullcap (Scutellaria galericulata L.) is less known specie...
Accumulation of phenolic compounds in the purple betony herb (Stachys officinalis L.) originated from cultivation
Introduction: Purple betony (Stachys officinalis L., Lamiaceae) is a perennial of versatile medicinal usage. Nowadays, in Poland betony herb is collected exclusively from wild growing plants. Decreasing number of its nat...
In vitro and in vivo evaluation of antitrypanosomal activity of Annona muricata stem bark extracts
The control of trypanosomosis in animals and humans based on chemotherapy is limited and not ideal, since the agents used are associated with severe side effects, and emergence of relapse and drug resistant parasites. Th...