Effect of Occupational Exposure to Aluminum on Parathyroid Hormone and Calcium Metabolism
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 11
Abstract
Aims: Aluminum is widely used in industry and it has been associated with several health hazards among exposed workers. To study the effect of aluminum on the parathyroid gland and the disturbance in calcium and phosphorus metabolism among workers exposed to aluminum in aluminum industry. Methodology: This study was conducted on fifty workers in an aluminum foundry, who were occupationally exposed to aluminum and were compared with fifty non-exposed individuals. Full history was taken, clinical examination and some laboratory investigations were done in the form of: CBC, kidney functions, serum PTH, serum calcium, serum phosphorus and serum aluminum. Plain X-ray was done for workers who were markedly complaining of musculoskeletal symptoms. Environmental measurement of aluminum dusts were carried out in selected workplaces. Study Design: Case control study of aluminum exposed workers. Place and Duration of Study: Aluminum industry in Ain-Helwan, Cairo, Egypt, 2012. Results: Statistically significant differences were found between exposed and control as regards prevalence of parathyroid and musculoskeletal disorders, serum level of the parathyroid hormone (PTH), serum calcium, serum phosphorus, serum aluminum, creatinine, RBCs count and also there was a statistically significant difference between exposed workers with osteopenia and exposed workers without osteopenia as regards serum aluminum level. The environmental measurements in the workplace were within the permissible limits in Egypt. Conclusion: The elevation of serum aluminum level in workers exposed to environmental level within the permissible limits was associated with disturbance in PTH, calcium and phosphorus metabolism, so these limits should be revised. Periodic medical examination of workers exposed to aluminum is a must; this should include clinical examination, analysis of aluminum in serum, measurement of serum electrolyte (calcium and phosphorus) and bone imaging.
Authors and Affiliations
Mona Sobhi Siha, Laila Rashed, Dalia Abdel-Hamid Shaker, Mona Ramadan
Keywords
Related Articles
- EP ID EP348726
- DOI 10.9734/BJMMR/2014/8153
- Views 73
- Downloads 0
Is There a Significant Renal Sonographic Difference between HIV/AIDs Positives and Negatives? A Developing Country Perspective
Background/Objectives: HIV/AIDS is a major health problem in the developing countries. It is a known cause of kidney failure especially in patients with HIV-Associated Nephropathy (HIVAN). Ultrasonography is a cheap and...
Proportion of Refractive Error and Its Associated Factors among High School Students in South India
Background: School children are a high risk population for refractive errors (REs). Uncorrected REs can adversely affect the learning abilities and mental development of school children. Objectives: This cross sectional...
Seroprevalence of Syphilis Infection in Individuals at Cape Coast Metropolis, Ghana
Background: Syphilis is a sexually transmitted infection caused by Treponema pallidum. The disease becomes very common among individuals with multiple sexual partners without protection. Aim: This research aimed at asse...
Evaluation of IL-10 and IL-12B Gene Polymorphisms on the Response to the Standard of Care Therapy in Chronic Hepatitis C Patients: An Egyptian Cohort Study
Background: Interleukin-10 (IL-10) and IL–12B single nucleotide polymorphisms (SNPs) are confirmed to influence the natural history of hepatitis C virus (HCV) infection, and the response to treatment. This work aimed at...
The Role of Bacterial Translocation in Development of Acute Intestinal Obstruction
Aim: Studying of quantity and quality content of intestinal microflora and abdominal cavity exudate in complex treatment of acute intestinal obstruction with addition of enterosorption. Materials and Methods: It was inv...