Effect of Ondansetron on Pain among rodents by Tail Flick Method and Eddy’s Hot Plate Method
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Introduction: 5-HT 3 receptors were involved in the regulation of both mood and pain. 5-HT3 receptors are present in many parts of the body including central nervous system, peripheral neurons, spinal cord, gastrointestinal tract etc. the present study was planned to evaluate its analgesic activity of ondansetron on pain in rodent models by two different models of pain viz tail flick method and eddy’s hot plate. Materials and Methods: Albino rats (Wistar) weighing 180-250 g and Swiss albino mice weighing between 25-30 gm were procured from the central animal house of Narayana Medical College, Nellore. Control animals (group I) received equal volume of normal saline. Ondansetron 0.25mg/kg,0.5mg/kg,1mg/kg and 2mg/kg were given once a day for seven days to group II, III , IV and V rats respectively for all the models. Statistical analysis was performed using Microsoft Excel-2007 and Sigma Graph pad prism version-5 USA. Results: In Tail flick method, OND of 1 and 2 mg/kg at 30 and 60 min showed significant (p<0.05) increase in mean reaction time as compared to control, whereas OND 2mg/kg at 90 min also showed significant (p<0.05) increase in mean reaction time as compared to control. DFC 10mg/kg showed significant (p<0.001) increase in mean reaction time as compared to control. In Eddy’s hot plate method Mean reaction time of OND in dose of 0.25, 0.5, 1 and 2mg/kg at 90 min was 4.0(1.6), 5.5(1.3), 5.8(1.4) and 7.3(1.9) respectively.OND of 2 mg/kg at 30, 60and 90 min showed significant (p<0.05) increase in mean reaction time as compared to control. DFC 10mg/kg showed significant (p<0.001) increase in mean reaction time as compared to control. Conclusion: The current study demonstrates high doses having significant analgesic activity in thermal procedures. This can be further substantiated with well controlled experimental and clinical studies.
Authors and Affiliations
Dr. S. Padma Sravani, Dr. G. V. Hemanth
Keywords
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- EP ID EP464641
- DOI 10.9790/0853-1802020409.
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