Effect of Ondansetron on Prevention of Ventilator Associated Pneumonia in Intensive Care Unit Patients in Kashani Hospital in 2013
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 8
Abstract
Introduction: Ventilator Associated Pneumonia (VAP) is the second most common infection with high mortality (24-50%). Ondansetron is a reliable and safe drug and it is currently used in the prevention of nausea and vomiting and has no side effects. Aim: The aim of the present study was to examine the effect of ondansetron on prevention of VAP in Intensive Care Unit (ICU) patients. Materials and Methods: The present study was a randomized clinical trial study (IRCT201406156480N6), carried out at Kashani Hospital, Iran, in 2013 on 80 patients aged from 15-65 years. The patients were randomly allocated to two groups: Case group (n=40) and Control group (n=40). The patients in first group were injected with 4 mg ondansetron, twice daily for five days. The patients of other group were injected with distilled water as placebo. The presence of VAP was assessed in the two groups. The collected data were analysed by SPSS software through Fisher-exact test. Results: Eleven (13.8%) patients were diagnosed with VAP. Among them, 9 (81.8%) patients were male and 2 (18.2%) patients were female. The incidence of VAP in Case group was 5 (12.5%) patients and in Control group was 6 (15%) patients (p>0.05). Results showed that VAP in Case group was less prevalent than that in the Control group, but this difference was not significant. Conclusion: The study did not find an association between ondansetron administration and reduction in VAP incidence; vomiting alone may not be leading to VAP, instead silent micro aspirations may be the cause of it. None of the factor such as age, sex, weight, smoking, drug addiction was found significantly related to VAP. Only variable found related was comorbidity
Authors and Affiliations
Hossein Madineh, Omolbanin Rahimi, MohamadReza Abedin Zadeh, Majid Kabiri
Keywords
Related Articles
- EP ID EP361459
- DOI 10.7860/JCDR/2017/25859.10424
- Views 77
- Downloads 0
Effect of Upper Limb Neural Mobilization on Vibration Threshold and Hand Grip Strength in Asymptomatic Individuals: A Randomized Controlled Trial
Introduction: Neural Tissue Mobilization (NTM) is a common technique used in clinical presentation with increased neural mechanosensitivity and was found to improve signs and symptoms. However, there is dearth in the lit...
Incidence and Association of HPV16 and 18 with Various Risk Factors in Cervical Cancer Patients in Population of Haryana Region, India
ABSTRACT Introduction: Cervical cancer is the most leading malignancy in women with the highest mortality rates in most of the countries and Human Papilloma Virus (HPV) 16 and 18 confer a greater risk of having cervical...
Comparative Evaluation of the Efficacy of Bioactive Ceramic Composite Granules Alone and in Combination with Platelet Rich Fibrin in the Treatment of Mandibular Class II Furcation Defects: A Clinical and Radiographic Study
Introduction: Predictable closure of furcation defects with bone grafts, Guided Tissue Regeneration (GTR) and a combination of the two has remained an elusive goal so far. Hence, evaluation of biomimetic agents as candid...
The Leverage Method: A Novel Technique for Difficult Temporomandibular Joint Reduction
Letter to Editor
Antibacterial Effects of Garlic Extracts and Ziziphora Essential Oil on Bacteria Associated with Peri-Implantitis
Introduction: Peri-implantitis is an inflammatory process, characterized by loss of bone around implants and bleeding on probing. Colonization of bacteria in the pocket created around the implant is one of the most impor...