Effect of Oral Clonidine Premedication on Perioperative Haemodynamic Response and Post Operative Analgesic Requirements for Patients Undergoing Laparoscopic Surgeries
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 4
Abstract
Background: The first focus on haemodynamic response to laryngoscopy and tracheal intubation was done in 1950 by Burstein. King et al in (1951) described the abnormal circulatory reaction to laryngoscopy. Its association with a rise in blood pressure, tachycardia and increased level of catecholamines was highlighted by Prys-Roberts in (1971) and by Siedlecki in 1975. Recognizing the hazardous effect of such reflex reactions, many techniques were studied and clinically tried to obtund these reactions. At the same time, The first publication on diagnostic laparoscopy by Raoul Palmer appeared in the early 1950s, followed by the publication of Frangenheim and Semm. Hans Lindermann and Kurt Semmpractised CO2 hysteroscopy during the mid-1970s. However this procedure is not risk free, In fact it produces significant changes in haemodynamically compromised patients.The hallmark of laparoscopy is creation of carbon dioxide pneumoperitonium and change in the patients position from trendelenburg to reverse trendelenburg. It also results in stress hormone responses (cortisol, epinephrine and non–epinephrine) especially when CO2 pneumoperitonium is used concomitantly. Laryngoscopy with or without tracheal intubation amounts to a highly noxious stimulus to the homeostasis of the patient. Aims: Designed to assess the effect of oral Clonidine premedication on hemodynamic response to endotracheal intubation and to compare intra-operative haemodynamic parameters, pain and sedation scores, time of first post-operative analgesia and dverse effects Material and Method: Total 60 patients ASA grade I and II in the age group 20 to 55 years were included in this study and they were randomly divided into two groups: Group 1 (n=30), patient received oral clonidine 150 mcg orally 90 min before induction Group 2 (n=30), patients received oral vitamin C 100 mg orally 90 min before induction All patients were posted for elective surgeries and were randomly selected. Conclusion: The basal and perioperative arterial blood pressure and heart rate after giving premedication was lower in clonidine group as compared to placebo group. Time for 1st post-operative analgesia requirement in clonidine group was significantly prolonged in comparison with the ranitidine group.
Authors and Affiliations
Rohan R. Nayak
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- EP ID EP535643
- DOI 10.21088/ijaa.2349.8471.5418.17
- Views 99
- Downloads 0
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