Effect of Oral Clonidine Premedication on Perioperative Haemodynamic Response and Postoperative Analgesic Requirement for Patients Undergoing Laparoscopic Cholecystectomy
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Objectives: Clonidine is a centrally acting sympatholytic agent with antihypertensive activity. It blunts stress response, provides analgesia, sedation and augments effects of anesthesia. Hence it was hypothesized to be an ideal agent to prevent stress response associated with laparoscopic surgeries and provide post-operative analgesia. Patients and Methods: 120 adult patients of ASA physical status I and II scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia were randomly allocated to receive oral clonidine (150 mcg) premedication (Group I, n=60) or placebo (Group II, n=60) 90 mins prior to induction. Intra-operatively they were managed by standard anesthetic agents. The two groups were compared in terms of hemodynamic parameters, sevoflurane concentrations at predetermined intervals during surgery, post-operative time to analgesic request and cumulative analgesic requirements. Results: Mean heart rate, blood pressure and sevoflurane concentration requirements at 1 and 5 mins after intubation, skin incision, start of pneumoperitoneum, 15 and 30 mins after pneumoperitoneum and 15 mins after release of pneumoperitoneum were significantly lower in clonidine group than in placebo group. Time to request of analgesic in clonidine group (150.72 ± 38.47) was significantly higher than that in placebo group(128 ± 28.5 minutes), (p= 0.0004). Total post-operative tramadol requirement in excess of 2 doses was only in 15% of patients in clonidine group vs 60% of patients in placebo group. Conclusions: Administration of oral clonidine premedication resulted in better hemodynamic stability and reduction of intra-operative anesthetic requirement and post-operative analgesia.
Authors and Affiliations
Gouranga Dutta, Soumedhik Dey, Shubhadeep Das, Nandini Das
Keywords
Related Articles
- EP ID EP440533
- DOI 10.9790/0853-1801116976.
- Views 33
- Downloads 0
A Study on The Analysis of Functional Outcome of Displaced Distal Third Tibio-Fibular Fractures Treated By Fibula Fixation And Tibial Interlocking Nailing
Background: Diaphyseal fractures in the tibia are one of the commonest ones encountered in clinical practice and of which the distal third involvement accounts for about one-fourth. Various treatment modalities have been...
Association of helicobacter Pylori Infection and Vitamin B12 Level among Sudanese Patients
Background:Helicobacter Pylori (H. Pylori) infection is a major gastric infection worldwide and has been associated with many hematologic disorders. Objective: The purpose of this study was to determine the association b...
“Think Twice Cut Once”Approach Using One Shape For Radix Endomolaris-A Case Report
This is a clinical case of a mandibular first molar with four root canals using a one shape rotary file system. Successful root canal treatment depends on proper cleaning, shaping and compact filling of the root canal un...
Surgical Management of Paediatric Humerus Fractures with Tens - A Retrospective Analysis.
Controversy persists regarding surgical management of long bone injuries in the agebetween 6 to 16 years. Titaniumelasticnail (TEN) fixation was originallymeantasanideal treatment method for femoral fractures, but was gr...
Designing Of an External Way Finding System for a Teaching Medical College
.