Effect of Oral Co-administration of Curcumin and Piperine on the Development of Induced Cutaneous Tumors in Mice
Journal Title: Journal of Ayurvedic and Herbal Medicine - Year 2018, Vol 4, Issue 2
Abstract
Turmeric is a yellow powder from the rhizomes of a herbaceous plant, Curcuma longa. Curcumin, a major component of turmeric, is a polyphenol that has anti-oxidant, anti-inflammatory and antiproliferative properties that give it an antitumor effect. Administration of oral curcumin appears few effective because of its low bioavailability but adjuvants such as piperine present in black pepper may improve this bioavailability. The aim of the present study is the evaluation the effect of curcumin and piperine-based regimen on the development and growth of chemo-induced cutaneous tumors in Swiss albino mice. A single topical application of 400 nmol of DMBA (7,12-dimethylbenz (a) anthracene) is followed one week later by the application twice a week of 5 nmol of TPA (12-O-tetradecanoylphorbol-13-acetate) during 10 weeks. DMBA/TPA-induced papillomas are evaluated in mice fed a standard diet or curcumin (0.5%) and piperine (0.005%) diet. Curcumin significantly inhibited the tumorigenic effect of DMBA and TPA by decreasing tumor incidence by 50%, tumor multiplicity by 38% and tumor volume by 90%. In addition, the histological study showed that the curcumin and piperine diet attenuated epidermal changes caused by DMBA/TPA treatment such as hyperplasia, cellular atypia and hyperkeratosis. Our study demonstrated that oral co-administration of curcumin and piperine has a significant inhibitory effect on DMBA/TPA-induced cutaneous tumorigenesis. Piperine, by increasing the bioavailability of curcumin, improves its chemoprotective and chemo-preventive efficacy against tumor development.
Authors and Affiliations
Siham Amsaguine, Omar Bouraymi, Najat El amrani, Driss Radallah
Keywords
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