Effect of oral low dose pregabalin on succinylcholine induced fasciculations and myalgia -A prospective randomized double blind placebo-controlled study
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 3
Abstract
IntroductionAmong the depolarizing muscle relaxants Succinylcholine is the widely used depolarizing agent until today in anaesthesia practice Side effects like hyperkalemia fasciculations myalgia increased intracranial pressure and intraocular pressure are common with the use of this drug Pretreatment with various drugs have been proven to lessen these side effects In our study low dose of oral pregabalin was used as a premedication to assess its effects on the incidence and severity of fasciculations and postoperative myalgia caused by Succinylcholine administrationMaterials and Methods 60 patients of either gender undergoing elective ENT surgeries under general anaesthesia were randomly allocated to two groups of 30 each Patients in Group PG pregabalin group received 75 mg of pregabalin orally 1 h prior to surgery and patients in Group CG control group received matching placebo Fasciculations and myalgia grading was done by a blinded observer Haemodynamic variables were measured at regular intervalsResults Both groups were comparable in regard to Demographic data p 005 We didnt find any significant difference in the fasciculations incidence p0702 and myalgia incidence p0081 between the two groups But the severity of fasciculations is statistically significant between the groups 0P 0Conclusion Low dose oral pregabalin 75 mg decreases the severity of succinylcholineinduced fasciculations and myalgia There is not much effect on the incidence of fasciculations and myalgia in patients undergoing elective ENT surgeriesKeywords Succinylcholine Low dose Pregabalin Fasciculations Myalgia
Authors and Affiliations
Hanumanthappa V. Airani, Rashmi H D
Keywords
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- EP ID EP476489
- DOI 10.18231/2394-4994.2018.0069
- Views 61
- Downloads 0
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