EFFECT OF ORLISTAT ON LEARNING AND MEMORY IN NORMAL AND MEMORY DEFICIT ANIMALS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: To investigate the possible effect of Orlistat on learning and memory in normal and memory deficit animals in two different age groups of mice.Methods: The effect of Orlistat on learning and memory was evaluated using Elevated plus maze and Rectangular plus maze screening methods on young and adult mice.Results: Three doses of Orlistat 5.4, 10.8 and 21.6 mg/kg, p. o were administered for 7 days and 15 days in experiments involving Elevated plus maze and Rectangular plus maze respectively in the separate group of animals. As a response to Elevated plus maze method adult and young mice showed the marked decrease in transfer latency (p<0.001) on 8th day when compared to negative control diazepam (1 mg/kg, i. p) indicating learning and retention of the learned task or memory in mice. Furthermore, in Rectangular plus maze the time taken by the mice to reach the reward chamber ‘B’ from the entry chamber ‘A’ in Orlistat treated animals was reduced. Orlistat 5.4 mg/kg did not show any significant impact on memory of young and old mice. Whereas Orlistat (10.8 and 21.6 mg/kg, p. o) dose proved to improve the memory in young as well as old mice.Conclusion: This study shows that Orlistat possesses learning and memory improving activity by inhibiting phospholipase A2 in mice models.Â
Authors and Affiliations
Zakia Banu A, Kavimani S
Keywords
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