Effect of perioperative glutamine administration on C-reactive protein and liver function tests in patients undergoing hepatic resection
Journal Title: Polish Journal of Surgery - Year 2014, Vol 86, Issue 1
Abstract
Hepatic resections are commonly associated with high morbidity and mortality. Nutrition plays an important role in reducing postoperative complications besides improvement in intensive care and perioperative management. The aim of the study was to evaluate the role of glutamine as an immunonutrient in patients undergoing hepatic resection. Material and methods. The study included 22 patients who underwent hepatectomy. Patients were randomized into two equal groups wherein group A patients received perioperative glutamine whereas group B patients served as controls. Primary outcome measures were level of serum albumin, C‑reactive protein (CRP), liver function tests and absolute neutrophil counts in the postoperative period while secondary outcome included post operative complications. Results. Glutamine decreased the CRP response in liver resection in a statistically significant manner (p=0.028) on the fifth post operative day. This may signify that glutamine decreases the post operative inflammatory response associated with liver resection. Glutamine did not have any significant effect on liver function tests. Postoperative morbidity was less in patients who received glutamine. Conclusion. Glutamine successfully blunted the CRP response in patients who received glutamine postoperatively. Decrease in morbidity following glutamine administration is an attractive area of prospective research and requires further consideration involving larger patient groups.
Authors and Affiliations
Vijay Richard, Divya Dahiya, Lileswar Kaman, Prithvi Raj, Arunanshu Behera
Keywords
Related Articles
- EP ID EP74337
- DOI 10.2478/pjs-2014-0003
- Views 92
- Downloads 0
Cell therapy in surgical treatment of fistulas. Preliminary results
Risk of recurrence after surgical treatment of a recurrent fistula is up to 50%. It has be known that more aggressive surgical treatment is associated with a high risk of anal sphincter damage and leads to incontinence....
Autogenous transplants of adrenal fragments in an animal model
Introduction Adrenal insufficiency is a typical complication after surgical treatment of adrenal tumors, especially after the removal of both adrenal glands. Human beings are not able to survive without adrenal glands an...
Evaluation Of Irritable Bowel Syndrome Symptoms Amongst Warsaw University Students
Irritable bowel syndrome (IBS) belongs to functional gastrointestinal disorders and is characterized by abdominal pain and change in stool consistency and/or bowel habits. Etiological factors include gastrointestinal per...
Morphological changes of the pancreas in course of acute pancreatitis during treatment with Ulinastatin
Acute pancreatitis is a severe clinical conditio that causes significant mortality in patients. Since we do not have at the moment effective causal treatment research on the use of pro tease inhibitors can produce tangib...
Gastrointestinal Tract Obstruction Due to Jejunal Adenocarcinoma – Case Report
The study presented a rare case of jejunal adenocarcinoma in a 60-year-old patient with symptoms of high subileus. No risk factors or coexisting diseases, which predispose towards intestinal cancer were detected. The stu...