Effect of perioperative glutamine administration on C-reactive protein and liver function tests in patients undergoing hepatic resection
Journal Title: Polish Journal of Surgery - Year 2014, Vol 86, Issue 1
Abstract
Hepatic resections are commonly associated with high morbidity and mortality. Nutrition plays an important role in reducing postoperative complications besides improvement in intensive care and perioperative management. The aim of the study was to evaluate the role of glutamine as an immunonutrient in patients undergoing hepatic resection. Material and methods. The study included 22 patients who underwent hepatectomy. Patients were randomized into two equal groups wherein group A patients received perioperative glutamine whereas group B patients served as controls. Primary outcome measures were level of serum albumin, C‑reactive protein (CRP), liver function tests and absolute neutrophil counts in the postoperative period while secondary outcome included post operative complications. Results. Glutamine decreased the CRP response in liver resection in a statistically significant manner (p=0.028) on the fifth post operative day. This may signify that glutamine decreases the post operative inflammatory response associated with liver resection. Glutamine did not have any significant effect on liver function tests. Postoperative morbidity was less in patients who received glutamine. Conclusion. Glutamine successfully blunted the CRP response in patients who received glutamine postoperatively. Decrease in morbidity following glutamine administration is an attractive area of prospective research and requires further consideration involving larger patient groups.
Authors and Affiliations
Vijay Richard, Divya Dahiya, Lileswar Kaman, Prithvi Raj, Arunanshu Behera
Keywords
Related Articles
- EP ID EP74337
- DOI 10.2478/pjs-2014-0003
- Views 129
- Downloads 0
Polish Consensus on Treatment of Gastric Cancer; Update 2013
Adrenal Tumors - Diagnostics and the Factual Situation
Preliminary Outcome of Treatment of Postoperative Primarily Closed Sternotomy Wounds Treated Using Negative Pressure Wound Therapy
Hospital infections, and in particular infections of the surgical site are a common problem of the procedural departments. Due to continuous progress of surgical techniques and patient population getting older with multi...
Zachorowalność, chorobowość i 5-letnie przeżycia chorych na raka jelita grubego w Województwie Kujawsko–Pomorskim w latach 2005–2011 na podstawie danych Narodowego Funduszu Zdrowia
Wstęp: Wskaźniki zachorowalności, chorobowości i 5-letnich przeżyć obrazują sytuację epidemiologiczną raka jelita grubego oraz oceniają efektywność podejmowanych działań leczniczych. W Polsce płatnikiem świadczeń jest Na...
Neurilemoma of the Median Nerve - Surgical Strategies Based on a Case Report
The study presented a case of a patient with a neurilemoma of the median nerve. It presented as a six centemeters tumor, at the level of the proximal one third of the arm with only mild paraesthesias within first to thir...