Effect of Phase I periodontal therapy on Interleukin-33 levels in periodontal disease.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
Background: Interleukin-33 (IL-33) is a novel member of the IL-1 superfamily. It has been identified as a dual function protein and a ligand for ST2 receptor, which plays a pivotal role in osteoclastogenesis. The aim of this study was to evaluate the IL-33 levels in gingival crevicular fluid (GCF) and plasma in subjects with chronic periodontitis, and to evaluate the effect of Phase I or non-surgical periodontal therapy on the GCF and plasma IL-33 levels. Materials And Methods: 60 subjects (age range: 30–56 years)) were selected and divided into groups based on the gingival index, probing pocket depth, clinical attachment level, and radiologic parameters (bone loss): Group H (30 subjects with healthy periodontium), Group CP-BT (30 subjects with chronic generalised periodontitis), while, Group CP-BT patients after 8 weeks of the treatment (scaling and root planing, SRP) constituted Group CP-AT. GCF samples and plasma samples were collected to estimate the levels of IL -33 using enzyme linked immunosorbent assay kit. Results: The mean IL-33 concentration in GCF and plasma was higher for Group CP-BT compared to Group H and decreased after non-surgical periodontal therapy in chronic generalised periodontitis group (CP-AT). The difference between them was statistically significant (p<0.001). Conclusion: IL-33 can be considered as an “inflammatory marker” of periodontal disease and health and has the potential to be a therapeutic target in the treatment of periodontal disease.
Authors and Affiliations
Dr. Sujatha Pai B.
Keywords
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