EFFECT OF POLYHERBAL PREPARATION ON THIOACETAMIDE INDUCED LIVER DAMAGE AND HEPATIC ENCEPHALOPATHY IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 6
Abstract
To evaluate the hepatoprotective activity of polyherbal preparation on thioacetamide (TAA) induced liver damage and hepatic encephalopathy in rats. Effect of 14 days treatment of polyherbal extract (PHE) (300 mg/kg and 600 mg/kg, p.o) was evaluated against thioacetamide (TAA) (200 mg/kg X 2, i.p.) induced liver damage and hepatic encephalopathy in rats. Serum ALT, AST, ALP, GGT, bilirubin and liver histological changes were assessed in control and PHE treated rats. The effect of PHE against hepatic encephalopathy was evaluated by the assessment of blood ammonia level, motor and cognitive activity and brain neurotransmitters such as dopamine, noradrenaline, serotonine and GABA in rats. Pretreatment with PHE significantly reduced liver enzymes level in blood as compared to TAA treated animals. PHE prevents the TAA induced elevation of ammonia level in blood. Pretreatment with PHE had significant protection against TAA induced changes in brain neurotransmitters level and impairment of motor and cognitive function. Histology of the liver sections confirmed that PHE prevented hepatic damage induced by TAA showing the presence of normal hepatocytes, absence of necrosis and fatty infiltration. The behavioral, biochemical and histological results indicated the protective effect of PHE against TAA induced liver damage and hepatic encephalopathy in rats.
Authors and Affiliations
Mehul Dhorajiya , Varsha Galani
Keywords
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