EFFECT OF POMEGRANATE (PUNICAGRANATUM L.) (ARILS, PEELS AND SEEDS) EXTRACTS ON FATTY LIVER IN RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 1
Abstract
Objectives: This study aimed to investigate the ameliorative effect of pomegranate extracts (arils, peels, and seeds) on nonalcoholic fatty liver disease in rats. Methods: The nonalcoholic fatty liver disease was induced by methionine choline deficient (MCD) diet. Different pomegranate extracts (arils, peels, and seeds) were administered orally at dose 5ml/kg/b.wt./day. Rats were divided into 2 groups. Group I healthy group were fed on standard diet and group II fatty liver group were fed on MCD diet. After a month of the experiment, Group I was subdivided into 4 groups as follows: G1 healthy control, G 2 pomegranate juice (healthy PJ), G 3 pomegranate peels extract (healthy PPE), and group 4 pomegranate seeds extract (healthy PSE). Also Group II was subdivided into 4 groups included: G5 (fatty liver control group), G6(fatty liver + PJ), G7(fatty liver + PPE) and G8(fatty liver + PSE). Results: The results indicated that MCD diet induced significantly hyperlipidemia, significantly elevated nitric oxide concentration and malondialdehyde level, and also significantly depletes reduced glutathione content, catalase, paraoxonase and arylesterase enzymes activities in liver. Moreover MCD diet significantly raised plasma pentaxin-3 and cytokeratin-18 concentrations and significantly elevated liver enzymes. However pomegranate extracts (PJ, PPE and PSE) significantly reduced hyperlipidemia, significantly depleted the elevation of oxidative stress markers and also significantly raised the antioxidants. Moreover, pomegranate extracts improved the liver function and significantly depleted markers for cell death. The results were confirmed by liver histopathology In conclusion: Pomegranate extracts administration attenuated the severity of nonalcoholic fatty liver disease in rats.
Authors and Affiliations
Prof. Dr. Gehan Salah El- Din Moram
Keywords
Related Articles
- EP ID EP666874
- DOI -
- Views 169
- Downloads 0
MYELOID SARCOMA AS THE PRESENTING SYMPTOM OF CHRONIC MYELOID LEUKEMIA CHRONIC PHASE: A CASE REPORT
Myeloid sarcoma is an extramedullary tumor of immature granulocytic cells. It is a rare condition; most often associated with acute myeloid leukemia but can be associated with myeloproliferative neoplasms or myelodysplas...
COCCINIA GRANDIS (L) VOIGT- REVIEW
The Cucurbitaceae family is commonly known as gourd, melon and pumpkin family. The family of Coccinia grandis (L.) Voigt, is Cucurbitaceous, comprises 960 species. (English name: ivy gourd) commonly known as “Kovai”, als...
AN SURVEY BASED ON RESEARCH METHODOLOGY AND ITS DEVELOPMENT IN SIDDHA SYSTEM
Research is an essential and a ladder to any field for its development But being an ancient system, our traditional system facing several difficulties to update in the field of research. As its principles are preternatur...
EVALUATION OF THE ACTIVITY OF NADIAH HERBAL FORMULA AGAINST NEISSERIA GONORRHEA
Objective: The gonorrhea infection is a major problem recently, and its resistance against different medications. Therefor the objective of this study was conducted to evaluation the activity of nadiah herbal against Nei...
“SEERAKA CHOORANAM” A SIDDHA FORMULATION FOR IRATHTHAK KOTHIPPU NOAI (HYPERTENSION)
Iraththak kothippu noai (Hypertension) is one of dangerous non communicable diseases in the world. National survey on health of Sri Lankans finds 18 percent of population suffers a chronic illness. Among the cases report...