Effect of Progressive Resistance Exercise Training on Hepatic Fat in Asian Indians with Non-Alcoholic Fatty Liver Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 1
Abstract
Introduction: Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity and insulin resistance and lifestyle measures form the cornerstone of therapy. Objective: To study the effect of progressive resistance training (PRT) on hepatic fat content, body composition and insulin sensitivity in patients with NAFLD. Methods: This study included 24 adult patients with NAFLD diagnosed on ultrasonography. Subjects with alcohol intake >140 gm/week and any secondary cause of fatty liver were excluded. Patients underwent thrice weekly sessions (40 minutes each) of resistance exercises including flexion at biceps, triceps, and hip flexion, knee extension and heel rise for 12 weeks. Pre- and post-intervention evaluation included anthropometry, BIA analysis, short insulin tolerance test (SITT), lipid profile and hepatic fat quantification by MRI. Results: Twenty four patients (17 males, 7 females, mean age 39.8±10.5 yrs) completed the study protocol with 78.7% compliance to PRT protocol. There was significant decrease in waist, hip and mid-thigh circumferences and skinfold thicknesses at biceps, triceps, subscapular and suprailiac regions (p<0.05), with no significant change in BMI and WHR. Insulin sensitivity improved significantly at 12 weeks as indicated by increase in k-value (rate of change of glucose) on SITT (0.84 vs 1.3, p=0.002). A decrease in total cholesterol and LDL-c with increase in HDL-c was noted after 12 weeks (p<0.05). Hepatic fat content also decreased at 12 weeks (22.3±3.9 vs 21.4±4.0 %, p=0.01). Conclusion: Moderate intensity PRT is associated with significant improvement in hepatic fat, truncal subcutaneous fat and insulin sensitivity in patients with NAFLD.
Authors and Affiliations
Kirti Damor, Kanchan Mittal, Ashu Seith Bhalla, Rita Sood, Ravindra M. Pandey, Randeep Guleria, Kalpana Luthra, Naval K. Vikram
Keywords
Related Articles
- EP ID EP348501
- DOI 10.9734/BJMMR/2014/4845
- Views 73
- Downloads 0
Stromal Tumor of the Jejunum Complicated by Hemorrhagic Shock-A Case Report
Stromal tumors of the small bowel, commonly known as GIST (Gastrointestinal Stromal Tumors) are mesenchymal tumors of uncertain prognosis. They develop in the wall of the digestive tract. They are usually asymptomatic, i...
In vitro Antimicrobial Activities of Ethanol Extract of Distemonanthus benthamianus (Aayan) Baillon (Fabaceae) on Streptococcus mutans
Objectives: The objective of this research was to evaluate the antimicrobial potential of Distemonanthus benthamianus on Streptococcus mutans. Methods: The antimicrobial activities of ethanol extract of Distemonanthus be...
Hepatitis C Virus Infection and Coronary Arteriosclerosis: The Growing Evidences
Arteriosclerosis is a chronic inflammatory vascular pathology that features a leading cause of coronary artery disease contributing to significant mortality and reduced quality of life. The recent identification of the p...
Delayed Dual-Time Point Imaging Protocol Improving Myocardial Uptake of 18-Fluorine Flouro Deoxyglucose (18F-FDG) During Viability Screening of Diabetes Mellitus Type 2 Patients Using Integrated Positron Emission Tomography/Computed Tomography (PET/CT) Imaging
Aims: To investigate the effect of delayed imaging protocol and hypoglycemic agent on quantitative values obtained during myocardial viability 18F-FDG PET/CT assessment. Presentation of Case: Mr. A, a 72 year-old man, Ma...
Performance of Nutritionally Optimized Millet Porridges in the Rehabilitation of Severely Malnourished Children at Mulago National Referral Hospital, Uganda
Aim: To evaluate the performance of nutritionally optimized millet porridges against F-100 which is a therapeutic food recommended by World Health Organisation for rehabilitating severely malnourished children. Study Des...