Effect of Prophylactic Antibiotic Use in the Development of Antibiotic Resistance in Children with Recurrent Urinary Tract Infections
Journal Title: HASEKİ TIP BÜLTENİ - Year 2017, Vol 55, Issue 3
Abstract
2017-04-05Aim:Although prophylactic antibiotic treatment is still debatable, it is currently in use in recurrent urinary tract infections (UTIs). In the present study, we aimed to observe if prophylactic antibiotic use had any effect on the development of antibiotic resistance in patients with recurrent UTIs who we followed up in our clinic. Methods: The present study was performed on patients aged between one month and 16 years, who had recurrent UTIs, and were followed up by the Department of Pediatrics at Bülent Ecevit University Medical School. Patient files were retrospectively reviewed, and 50 patients who received antibiotic prophylaxis and 100 patients without prophylaxis were enrolled in the study. Urinary tests, subsequent urinary culture results, and antibiotic resistances were compared between the groups. Results: The mean age was 42.7±44.2 months. The most frequently cultured isolated bacterium was Escherichia coli (E. coli) (58.4%). No difference was determined in bacteria in cultures between prophylaxis receivers and non-receivers. Isolation rate of E. coli was higher in urinary cultures in females than in males (p<0.001). When antibiotic resistance of all urinary culture-isolated bacteria was compared between the two groups, there was no statistically significant difference. However, an increased resistance against amoxicillin/clavulanic acid, ceftriaxone, and piperacillin was determined in prophylaxis group in whom E. coli was grown. In this study, general antibiotic resistance was most frequently observed against ampicillin (71.9%). Conclusion: In the present study, we observed that prophylaxis did not contribute so much to resistance other than E. coli. We recommend not preferring antibiotics which have increased resistance in our institution especially in children receiving prophylaxis for empirical treatment.
Authors and Affiliations
Mehmet Karacı, Kazım Karagöz, Zühal Örnek, Adem Yaşar, Necla Yüce, Özgür Okumuş
Keywords
Related Articles
- EP ID EP228215
- DOI 10.4274/haseki.98608
- Views 93
- Downloads 0
Peroneal Pseudoaneurysm as a Complication of Emergency Thromboembolectomy and Treatment with Coil Embolisation
Peroneal pseudoaneurysm is a rarely seen as a complication due to a variety of treatment strategies. Continuous blood flow and decreased vascular wall support associated with pseudoaneurysm can cause rapid enlargement, c...
The Role of Infections in Atopic Diseases in Children
Aim: Especially in the developed countries; there has been an increase in the prevalence of atopic diseases over the past 40 years. This is explained by the improved living conditions and reduced exposure to infections....
Association Between Cardiothoracic Ratio and Mortality in Neonates with Pneumothorax
Aim: The aim of this study was to determine the effect of a reduction in the cardiothoracic ratio (CTR) on mortality in newborns with pneumothorax. Methods: Newborns with pneumothorax, who were admitted to our neonatal i...
Distribution of the Rate of Morbidity and Mortality Developing After Surgical Treatment of Non-small Lung Cancer Surgery by Years
Aim: The most effective treatment for lung cancer is surgery. Morbidity rates remained almost constant over the years. However, morbidity rates have started to decline with better management of preoperative and postopera...
Emergency Department Management Following the Sultanahmet Square Suicide Bombing in İstanbul: One Hospital’s Experience
.